Janus Duo Tablet 50/1000 mg

Adult dose

This medication is generally taken twice daily with food, and to reduce gastrointestinal side effects due to metformin, the dosage should be increased gradually. 1. For patients not currently treated with metformin: Take this medication 50/500 mg twice daily, one tablet each time, and can increase to 50/1000 mg, taking one tablet twice daily. 2. For patients already receiving metformin treatment:

This medication consists of two components: sitagliptin and metformin. First, during the use of this medication, severe allergic reactions may occur, so if symptoms such as rash, hives, difficulty breathing, or swelling of the face or neck occur, discontinue use immediately and consult a physician. Second, serious side effects such as acute pancreatitis, which involves inflammation of the pancreas, have been reported; therefore, if symptoms such as abdominal pain, nausea, or vomiting appear at the onset of treatment or during therapy, inform medical personnel immediately. Third, metformin included in this medication can rarely cause lactic acidosis, a serious metabolic disorder that can be life-threatening; therefore, special caution is needed if there are conditions such as severe dehydration, heart disease, liver disease, severe infections, or excessive alcohol consumption. Fourth, patients with moderate to severe impaired renal function or acute diseases affecting renal function such as acute heart failure, myocardial infarction, or sepsis should not use this medication. Fifth, during therapy with this medication, regular kidney function and blood tests should be performed to check for abnormalities, and periodic assessment of vitamin B12 levels is recommended. Sixth, irregular meals, strenuous exercise, and concomitant use of other blood glucose-lowering agents may increase the risk of hypoglycemia; therefore, symptoms should be monitored, and if necessary, consult a physician to adjust the medication dosage. Seventh, if undergoing surgery or contrast imaging tests, this medication should be temporarily discontinued and resumed only after confirming normal kidney function post-examination. Eighth, it is safer for pregnant or breastfeeding women and children under 18 years of age not to use this medication. Lastly, during the use of this medication, excessive alcohol consumption should be avoided, and if any unusual symptoms occur, immediate consultation with medical personnel is required.

Serious side effects

• Hives
• angioedema
• anaphylaxis
• Stevens-Johnson syndrome
• exfoliative dermatitis
• acute pancreatitis
• acute renal failure
• respiratory distress
• bullous pemphigoid
• severe and disabling arthralgia

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal pain
• upper respiratory infection
• nasopharyngitis
• headache
• hypoglycemia
• constipation
• myalgia

This medication should be stored in a tightly sealed container to prevent air ingress, and it is advisable to keep it at room temperature between 1 and 30 degrees Celsius. Following this storage method can help maintain the effectiveness of the medication for an extended period.

Appearance

Dark red oval film-coated tablet

Package unit

30 tablets/bottle, 120 tablets/bottle