Daplogin 5 mg (Dapagliflozin Propanediol Monohydrate)

Adult dose

The recommended dosage of this drug is 10 mg once daily for monotherapy and as an adjunct to other blood sugar-lowering agents including insulin. In initial combination therapy, when administered with metformin, the daily dose may be 5 mg or 10 mg once daily. This drug can be taken orally at any time during the day, regardless of meals. The tablet should be swallowed whole.

Child dose

The safety and efficacy of Dapagliflozin in patients under 18 years of age have not been established.

This drug should not be used in certain patients. For example, it is not to be administered to those with allergies to the components or additives, patients with type 1 diabetes, diabetic ketoacidosis, or patients undergoing dialysis. Caution is required in patients with reduced fluid volume or impaired kidney function. This drug may lower blood pressure and affect kidney function, so fluid status and kidney function must be evaluated before administration, and symptoms of hypotension and changes in kidney function should be monitored after administration. In patients with moderate to severe kidney dysfunction, blood sugar control effects may decrease, and it is not recommended for patients with very low kidney function. Using this drug may lead to adverse reactions such as genital infections, urinary tract infections, hypoglycemia, decreased fluid volume, diabetic ketoacidosis, and rarely, Fournier's gangrene. Especially, genital and urinary tract infections appear more frequently in women and patients with a history of such infections. The risk of hypoglycemia may increase when used with other blood sugar-lowering agents such as insulin or sulfonylureas, and dosage adjustments may be required in such cases. Patients at risk of reduced fluid volume and hypotension, particularly the elderly or those on diuretics, should be more cautious, and should consult healthcare providers immediately if symptoms occur. Pregnant women or nursing mothers are advised not to use this drug, and should discontinue use if pregnancy is confirmed. The safety and efficacy of this drug in children have not been established, so it is not used in pediatric patients. In case of overdose, there is no specific antidote, so treatment should be received according to symptoms under medical supervision. This drug does not significantly affect driving or machine operation, but caution is needed in cases of hypoglycemia. Finally, this drug must be stored out of the reach of children and kept in its original container to maintain quality.

Serious side effects

Urticaria, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, oral/ocular mucous membrane pain, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities with cough and fever, jaundice of the skin or eyes, extreme lethargy, sudden and severe headache, thunderclap headache, seizure, confusion, visual disturbances, paralysis, markedly reduced urine output

Mild side effects

• Vulvitis
• balanitis
• genital infection
• urinary tract infection
• fungal infection
• hypoglycemia
• dry mouth
• dizziness
• constipation
• dry mouth

This drug should be stored in a sealed container to protect it from air and moisture. The storage temperature should ideally be maintained between 1 to 30 degrees Celsius.

Appearance

Yellow round film-coated tablet

Package unit

Box - 28 tablets/box [7 tablets/Alu-Alu x 4], Bottle - 28 tablets/bottle, Bottle - 30 tablets/bottle