Sitagliptin Metformin Duo Tablet 50/1000 mg

Adult dose

This medication is generally taken twice daily with food, gradually increasing the dose to minimize gastrointestinal adverse effects caused by metformin. 1. For patients not treated with metformin: the initial dose is one 50/500 mg tablet twice a day, which can be increased to one 50/1000 mg tablet twice a day. 2. For patients being treated with metformin: the recommended initial dose is sitagliptin 50 mg 1

This medication is a combination product containing sitagliptin and metformin and is used for blood sugar control in patients with type 2 diabetes. While taking this medication, severe allergic reactions may occur; therefore, if symptoms such as rash, hives, difficulty breathing, or swelling of the face or lips appear, discontinue use immediately and consult a physician. If symptoms of acute pancreatitis such as severe abdominal pain, vomiting, or nausea occur, stop taking this medication immediately and visit a hospital. This medication should not be administered to patients with severely impaired renal function or those suffering from severe infections, dehydration, acute heart failure, or acute myocardial infarction, and it should be temporarily discontinued before and after procedures requiring iodinated contrast agents. It is advisable for pregnant women or those who may become pregnant, as well as nursing mothers, not to use this medication. This medication can cause a rare but serious metabolic disorder known as lactic acidosis; therefore, if symptoms such as muscle pain, fatigue, difficulty breathing, abdominal pain, or unusual changes in consciousness occur, seek medical attention immediately. Hypoglycemia symptoms may manifest if blood sugar drops too low; thus, be especially cautious about these symptoms if taking insulin or sulfonylureas concurrently and consult a physician if necessary to adjust the dose. Regular monitoring of renal function, blood tests, and vitamin B12 levels is essential during the use of this medication. Be cautious of blood sugar control being affected by vigorous exercise, irregular eating, or interactions with other medications. If surgery is planned, discontinue this medication 48 hours prior to the procedure and restart only after confirming normal renal function post-surgery. Consumption of alcohol may increase the risk of lactic acidosis; therefore, excessive drinking should be avoided during treatment. Common side effects associated with this medication include diarrhea, nausea, vomiting, headache, and upper respiratory infection, while severe side effects may include joint pain or skin rash, and blistering diseases. If these symptoms arise, it is important to consult with a physician to receive appropriate measures. Elderly patients may have a higher risk of decreased renal function and thus require careful adjustment of this medication's dosage and monitoring of renal function.

Serious side effects

• Hives
• angioedema
• anaphylaxis
• Stevens-Johnson syndrome
• exfoliative dermatitis
• acute pancreatitis
• acute renal failure
• difficulty breathing
• severe and debilitating joint pain
• blistering dermatitis

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal pain
• upper respiratory infection
• nasopharyngitis
• headache
• hypoglycemia
• constipation
• asthenia

This medication should be stored in a tightly sealed container to prevent air from entering, at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the drug's efficacy over a long period.

Appearance

Pink oval film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP x 3]