Famciclovir 750 mg Tablet

Adult dose

1. Treatment of herpes zoster Adults: Administer famciclovir 750 mg orally once daily for 7 days. Take it at the same time each day. It is preferable to start treatment as soon as symptoms appear after infection. 2. Patients with renal impairment: Because the creatinine clearance of this drug is reduced in patients with renal impairment, dose adjustment should be undertaken with caution. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster Creatinine clearance (mL/min/1.73㎡) 30～59 250 mg per dose, twice daily 10～29 250 mg per dose, once daily 2) If only serum creatinine is known, creatinine clearance can be calculated using the following equations. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 3) Patients with renal impairment undergoing hemodialysis: For patients undergoing hemodialysis, administration every 48 hours is preferable, taking the interval between dialysis sessions into account. Since 4 hours of hemodialysis reduces the plasma concentration of this drug by approximately 75%, administer the full dose of this drug immediately after dialysis. 3. Patients with hepatic impairment: No dose adjustment is necessary in patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, a clear recommended dose has not been established.

This medication should not be used in patients with hypersensitivity to this medication, its components, or the active ingredient, penciclovir. Patients with impaired renal function should use this medication with special caution, and dosage adjustments may be necessary depending on renal status. During the use of this medication, symptoms such as headache or nausea may occur, which are mostly mild. However, rare reports of blood abnormalities such as thrombocytopenia or leukopenia have been noted, so caution is advised. Neurological side effects may include dizziness, confusion, drowsiness, and hallucinations; it is advisable to avoid driving or operating machinery if these symptoms occur. Gastrointestinal symptoms such as nausea, vomiting, abdominal pain, and diarrhea may commonly occur. Liver function abnormalities or jaundice may occur rarely, so patients with liver health issues should be cautious. Allergic reactions may manifest as skin rashes, itching, hives, or swelling around the face and eyes, and severe skin reactions have been reported rarely. In patients with poor renal function, there is a risk of acute kidney failure; thus, renal status should be closely monitored. This medication does not completely cure genital herpes, and it is recommended to avoid sexual contact and maintain safe sexual relations during treatment, even if symptoms are present. Women who are pregnant or may become pregnant should carefully consider the benefits and risks of using this medication, and breastfeeding women should also use it with caution. It is advisable not to use this medication in children under 18 years of age, as safety and efficacy have not been established. Generally, elderly patients do not require dose adjustments; however, adjustments may be needed if renal function is impaired. This medication may interact with other drugs; therefore, especially when taken with medications like probenecid or lamotrigine, it is important to consult healthcare professionals. In case of overdose, appropriate supportive treatment is necessary, and blood dialysis can help lower drug concentration. This medication should be stored in a dry place below 30 degrees Celsius, and kept out of reach of children. Care should be taken as transferring to another container may cause accidents or degrade the quality of the medication.

• headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This medication is sensitive to air and moisture and should be stored in a sealed container. Additionally, it should be stored in a dry place below 30 degrees Celsius to maintain efficacy.

Appearance

White oblong film-coated tablet

Package unit

7 tablets/PVC