Dapagliflozin and Metformin Extended-Release Tablets 10/1000 mg

Adult dose

This medication is usually administered once daily with the evening meal. The maximum dosage is dapagliflozin 10 mg/metformin extended-release 2000 mg once daily, taken as 2 tablets of 5 mg/1000 mg. If there has been no previous experience in diabetes pharmacotherapy, the initial therapy is 1 tablet of 5 mg/500 mg or 10 mg/500 mg once daily. For patients already on metformin therapy, the recommended dose of dapagliflozin is 10 mg once daily.

This medication is used for the treatment of type 2 diabetes and helps control blood sugar levels. While taking this medication, caution is required as a rare but serious side effect called lactic acidosis may occur. Lactic acidosis is a state where excessive lactic acid accumulates in the body, leading to symptoms such as difficulty breathing, muscle pain, lethargy, abdominal pain, and if any of these symptoms appear, consult a doctor immediately. Additionally, when taken with other diabetes medications such as insulin or sulfonylureas, hypoglycemia can occur, so blood sugar levels should be frequently monitored. Patients with impaired kidney function, dehydration, serious infections, heart problems, or liver dysfunction should not take this medication. Especially, patients with moderate to severe renal impairment should be very cautious or strictly contraindicated from taking this medication. Those scheduled for surgery or undergoing tests using iodinated contrast media should temporarily discontinue this medication before and after the procedure, resuming only after normal kidney function has been restored. Pregnant or breastfeeding women should not take this medication, and its safety and efficacy in children have not been established. This medication should be used with caution in patients at risk for decreased fluid volume or hypotension, especially the elderly or those on diuretics, and blood pressure and kidney function should be periodically monitored. During treatment, genital infections or urinary tract infections may occur, so prompt treatment should be sought if infection symptoms appear. Vitamin B12 levels may decrease, so it is advisable to check vitamin B12 levels with blood tests during prolonged use. Excessive alcohol consumption should be avoided as alcohol can increase the risk of side effects from this medication. While taking this medication, there may be interactions with other drugs, so it is important to inform your doctor or pharmacist of any other medications you are taking. In case of overdose, seek medical attention immediately, as this medication can typically be removed through dialysis. Finally, this medication should be kept out of the reach of children and stored in its original container to maintain quality.

Serious side effects

Lactic acidosis, severe hypoglycemia, serious lactic acidosis (reported fatalities), severe allergic reactions (history of hypersensitivity), acute kidney injury, renal impairment, cardiovascular collapse (shock), acute myocardial infarction, sepsis, acute or chronic metabolic acidosis, diabetic precoma, congestive heart failure, acute cholecystitis, Guillain-Barré syndrome, bacterial pneumonia, sialadenitis, atrial fibrillation, ketoacidosis, urosepsis, pyelonephritis, rash, perineal necrosis,

Mild side effects

• Vulvovaginitis
• balanitis and related genital infections
• urinary tract infections
• fungal infections
• hypoglycemia
• fluid volume reduction
• dry mouth
• dizziness
• constipation
• back pain

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. The storage temperature should be maintained between 1 degree and 30 degrees Celsius at room temperature. Proper storage ensures the safety and efficacy of the medication.

Appearance

Yellow to deep yellow, biconvex, oval, film-coated tablet

Package unit

30 tablets/box [6 tablets (Alu-Alu) X 5], 30 tablets/bottle