International Hyaluronate Injection (Sodium Hyaluronate)

Adult dosage

As sodium hyaluronate, inject 25mg once a week for 5 consecutive weeks into the intra-articular space of the knee or shoulder joint (shoulder joint cavity, subacromial bursa, or biceps brachii tendon). The number of injections can be adjusted according to symptoms. This drug is administered intra-articularly, so it must be conducted under strict aseptic conditions.

This drug should not be used in certain patients. First, it should not be administered to patients who have had an allergic reaction to this drug or its components. Additionally, since it is injected directly into the joint, it should not be used in patients with skin diseases or infections at the injection site. Patients with liver function problems or a history of liver disorders should also use this drug with caution, as liver function test values may become abnormal. Patients allergic to avian proteins should avoid this medication. When using this drug, adverse reactions may occur, so careful observation is required. A severe allergic reaction, known as shock, may occur, so if any unusual symptoms appear, administration should be stopped immediately and appropriate treatment sought. Reactions such as swelling of the face or eyelids, rash, hives, and itching may occur, and if these symptoms occur, use should be halted. Temporary pain, swelling, redness, warmth, pressure, or bruising at the injection site may occur, and nausea, vomiting, fever, and headache may rarely occur. This drug may worsen inflammatory symptoms in patients with severe arthritis, so it is advisable to use it after inflammation has subsided. After injection, care should be taken to stabilize the injection site and prevent leakage of the drug from the joint. In patients with rheumatoid arthritis or gouty arthritis, inflammation may temporarily increase, so caution is advised. It is also best to avoid vigorous exercise or weight-bearing activities for 48 hours after injection. The safety and efficacy of using this drug in conjunction with other intra-articular injectables have not been established, so it is preferable not to combine them. Women who are pregnant or may become pregnant should use this drug cautiously, as its safety has not been established, and only when the benefits of treatment outweigh the risks. Furthermore, this drug can be transmitted through breast milk, so breastfeeding should be avoided during administration. The safety of this drug in children is not certain, so it should be used cautiously only when absolutely necessary. Elderly patients may have decreased body function, so administration should be done with even more caution. Strict aseptic conditions should be maintained during injection, and it should not be administered more than 5 times if symptoms do not improve. It is advisable to drain excess joint fluid before injection. Intravenous administration is prohibited, and it is not for ophthalmic use. This drug is viscous, so it is recommended to use a properly sized syringe needle when putting it into a syringe and when administering it. After ensuring that the liquid in the ampule flows properly, it should be slowly aspirated, and when cutting the ampule, it should be done after disinfection to prevent foreign substances from entering. Care should be taken as mixing with disinfectants like benzalkonium chloride or chlorhexidine may result in precipitation. It should be used as a single dose and discarded promptly after opening.

Serious side effects

• Hives
• swelling (face, eyelids, etc.)
• shock

Mild side effects

• Facial flushing
• itching
• pain
• swelling
• edema
• redness
• warmth
• severe localized pressure
• petechiae
• nausea

This drug should be stored in a sealed container to prevent exposure to air, and the storage temperature should be maintained between 1 degree and 30 degrees Celsius (room temperature). Therefore, it is best to avoid places that are too hot or too cold, and to keep it in a cool place out of direct sunlight.

Appearance

A transparent viscous liquid filled in a glass tube sealed with rubber caps at both ends (part of a pre-filled syringe system)

Package unit

2.5 milliliters × 10, 50, 100 syringes