Vancomycin Injection 500 mg (Vancomycin Hydrochloride)

Adult dosage

As vancomycin, 500 mg (potency) should be given as an intravenous drip every 6 hours or 1 g (potency) should be given every 12 hours. For oral administration, 500 to 2000 mg should be divided and given 3 to 4 times a day for 7 to 10 days, with the total daily dose not to exceed 2 g.

Children's dosage

Pediatric patients should receive 10 mg (potency) per kg of body weight every 6 hours by intravenous injection. Infants should receive 10 to 15 mg (potency) per kg of body weight every 12 hours by intravenous injection. For infants and newborns, an initial dose of 1

This drug should not be used in patients who have previously experienced severe allergic reactions or shock due to this medication or peptide or aminoglycoside antibiotics. Additionally, caution should be taken in patients with hearing impairment or renal dysfunction, elderly patients, premature infants, and newborns. When using this medication, symptoms such as neurological disturbances, gastrointestinal symptoms, blood abnormalities, hearing loss, liver and kidney dysfunction, skin reactions, and allergic reactions can occur, so symptoms should be closely monitored. In particular, if the infusion rate is fast, red spots or pain on the face and body, or muscle cramps may appear, so it is important to infuse slowly. This medication can affect renal function, thus regular blood tests and renal function monitoring are required, and administration should be stopped immediately if abnormal symptoms appear. Furthermore, prolonged use of this medication can disrupt the normal intestinal flora balance and lead to diarrhea or gastroenteritis, so medical consultation should be sought immediately in case of symptom occurrence. This medication can interact with other drugs, so particular care should be taken when used in conjunction with anesthetics or medications that affect the kidneys and nervous system. Pregnant or breastfeeding women should consult a physician before using this medication and, if necessary, monitor blood concentrations to minimize effects on the fetus and newborn. Doses may require adjustment and careful observation in children and elderly individuals who may have reduced renal function. In cases of overdose, kidney damage or hearing impairment may occur, necessitating immediate medical attention, and this medication is not easily removed by dialysis, so special treatment measures may be required. When administering intravenously, it should always be diluted and infused slowly, and the site of infusion should be regularly monitored to avoid inflammation or pain. This medication may become unstable when mixed with other antibiotics, so avoid mixed administration and always check the condition of the solution before administration. Finally, although this medication works by inhibiting bacterial cell wall synthesis to treat infections, some bacteria may develop resistance, so it should be used appropriately based on sensitivity testing.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweats, pallor, severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa, asthma attack, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes, extreme lethargy, severe headache, lightning headache, seizures, confusion, visual disturbances, paralysis, significantly reduced urine output, severe generalized swelling, elevated blood pressure, shock, anaphylaxis.

Mild side effects

• Loose stools
• diarrhea
• nausea
• vomiting
• abdominal pain
• anemia
• leukopenia
• thrombocytopenia
• eosinophilia
• dizziness

This medication should be stored in a sealed container to prevent exposure to air, maintaining a temperature between 1 to 30 degrees Celsius (room temperature). This helps to prolong the effectiveness of the medication and prevent degradation.

Appearance

A colorless and transparent vial containing a white to light brown freeze-dried powder for injection.

Package unit

10 vials/box [500 mg potency/vial]