PR Diclofenac Injection (Diclofenac Sodium)

Adult dosage

Oral: The initial dose of diclofenac sodium is 100-150 mg per day; if symptoms are alleviated or for long-term use, it is administered at 75-100 mg per day divided into 2-3 doses. Injection: Administer 75 mg (1 ampoule) intramuscularly deep into one side of the upper buttock once a day. In severe cases, it may be given twice a day at 75 mg (1 ampoule) each time, alternating between both buttocks. Sustained-release formulation: 100 mg once daily orally

Children's dosage

Administer 0.5-3 mg per kg of body weight divided into 2-3 oral doses per day. Adjust according to age, condition, and symptoms.

This drug may cause gastrointestinal bleeding in individuals who regularly consume more than three glasses of alcohol daily, so it is essential to consult with a doctor or pharmacist. This drug may affect the cardiovascular system, increasing the risk of serious issues such as heart attack or stroke. Individuals with cardiovascular diseases or risk factors should exercise additional caution and seek immediate medical advice if symptoms occur. This drug can cause severe issues like gastrointestinal bleeding, ulcers, and perforations; thus, elderly individuals or those with a history of gastrointestinal diseases should use it cautiously. If symptoms of gastrointestinal bleeding occur during medication, immediate treatment should be sought. Severe allergic reactions may manifest symptoms such as chest pain; therefore, if allergic symptoms appear, inform healthcare personnel immediately and discontinue use. When using ampoule injections, care should be taken to avoid glass fragments; particularly so for children and the elderly. Patients with peptic ulcers, severe liver or kidney disease, severe hypertension, heart failure, or allergies to any of the components of this drug should not use it. Patients with a history of peptic ulcers or abnormalities in liver, kidneys, blood, hypertensive or cardiac patients, asthmatics, the elderly, and children should use this drug with caution. This drug can rarely cause a range of side effects including shock, gastrointestinal bleeding, blood abnormalities, skin rashes, liver dysfunction, kidney damage, asthma attacks, central nervous system abnormalities, visual disturbances, and heart issues; any unusual symptoms should lead to immediate cessation of use and consultation with a doctor. This drug should be used at the minimum effective dose for the shortest duration possible, and regular blood tests and liver and kidney function tests should be conducted during prolonged use. The risk of side effects may increase when taken with other non-steroidal anti-inflammatory drugs or certain medications, so it is essential to consult with an expert before concomitant use. During pregnancy, especially in the late stages, this medication may pose risks to the fetus, so it should be avoided, and during lactation, it can pass into breast milk and harm the infant, necessitating cessation of breastfeeding or discontinuation of the medication. Neonates or children may have difficulty regulating body temperature, hence it is necessary to be cautious due to the risk of excessive hypothermia. The elderly also face a higher risk of side effects and should take the minimum dose with caution. In cases of overdose, symptoms such as hypotension, renal failure, seizures, gastrointestinal disorders, and respiratory depression may occur, in which case immediate medical care should be sought.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory disturbances accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urinary symptoms

Mild side effects

• Rash
• itching
• thrombocytopenia
• anemia
• leukopenia
• agranulocytosis
• aplastic anemia
• hemolytic anemia
• purpura
• allergic purpura

This medication should be stored in a sealed container that blocks light and kept at room temperature between 1 and 30 degrees Celsius. This storage condition helps maintain the drug's efficacy and prevents deterioration.

Appearance

Colorless or pale yellow solution in brown ampoules

Package unit

50 ampoules/box[(2 milliliters/ampoule)]