Plaris 300 mg Tablets (Clopidogrel Sulfate)

Adult dose

Clopidogrel 300 mg is used only as a loading dose. 1. For patients with ischemic stroke, myocardial infarction, or peripheral artery disease, 75 mg should be taken orally once daily. 2. For patients with acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), start with a loading dose of 300 mg on the day of initiation, then maintain with 75 mg orally once daily.

This medication may be less effective in individuals with genetically reduced CYP2C19 enzyme function; alternative treatment options should be considered in these cases. Co-administration of this drug and medications that increase CYP2C19 enzyme activity may increase drug concentration, leading to an increased risk of bleeding; thus, concurrent use should be avoided. This drug should not be administered to patients with a known allergy to this medication or its components, as well as patients with bleeding disorders, severe liver damage, nursing women, and certain genetically lactose intolerant patients. Caution is required for patients at high risk of bleeding or those planning surgery; if any bleeding symptoms occur, immediate consultation with medical staff is necessary. Especially when taken with anticoagulants like warfarin, the risk of bleeding may increase, so careful use is required. This medication inhibits platelet function and extends bleeding time, thus usage should be adjusted in situations where bleeding is a concern. While taking this medication, gastrointestinal bleeding, skin rash, and hematologic abnormalities may occur; any abnormal symptoms should be reported to medical personnel immediately. During pregnancy or breastfeeding, it is important to consult a physician regarding the use of this medication, particularly to consider the timing of discontinuation to mitigate bleeding risks around delivery. Elderly patients or those with impaired kidney and liver function require careful observation when taking this medication. In cases of overdose, the risk of bleeding may increase, so it is essential to adhere to prescribed doses and regimens; severe bleeding may require platelet transfusion or other treatment. This medication has not been sufficiently confirmed for safety and efficacy in children, so it is advisable not to use it in pediatric patients. This medication may interact with other drugs, so inform medical professionals of any other medications being taken.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, peeling skin, oral/ocular mucosal pain, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, urination

Mild side effects

• Chest pain
• accidental injury
• influenza-like illness
• pain
• fatigue
• edema
• hypertension
• headache
• dizziness
• abdominal pain

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. It is advisable to maintain a storage temperature between 1 and 30 degrees Celsius to ensure the drug's effectiveness and safety.

Appearance

Pink oval film-coated tablet

Package unit

2 tablets/box [(1 tablet/PTP*2)]