Emplazine 25 mg (Empagliflozin)

Adult dose

The recommended dosage of this medication is 10 mg once a day for both monotherapy and additional combination therapy with other glucose-lowering agents like insulin. If well-tolerated and further blood glucose control is needed, the dose can be increased to 25 mg once a day. This medication can be administered regardless of meals, and the tablet should be swallowed whole. If a dose is missed, it should be taken as soon as remembered, but do not take two doses in one day.

This medication should not be administered to certain patients. First, patients who are allergic to the main component or any ingredients of this medication should not take it. Also, it should not be used in patients with Type 1 diabetes or diabetic ketoacidosis. Patients with severely decreased kidney function with a glomerular filtration rate (GFR) less than 30 mL/min/1.73m2, those with end-stage kidney disease, or those on dialysis should not take this medication. This drug contains lactose, so it should not be administered to patients with lactose intolerance, galactose intolerance, or congenital lactase deficiency. Caution should be taken when administering to patients with slightly reduced kidney function. It is advisable not to initiate this medication in patients with a GFR less than 60 mL/min/1.73m2, and if administered, the dose should be adjusted. If GFR continues to drop below 45 mL/min/1.73m2, the medication should be discontinued. In patients with end-stage kidney disease or those undergoing dialysis, the effectiveness of this drug is not expected, and it should not be used. In patients with mild to moderate heart failure, this medication should be used with caution; it is not recommended in patients with severe heart failure. If using glucose-lowering agents like insulin or sulfonylureas together, the risk of hypoglycemia may increase, so the dose of those agents may need to be reduced when used in conjunction with this medication. During treatment with this medication, symptoms of hypoglycemia may occur, so blood glucose should be monitored regularly, and if any abnormal symptoms arise, immediate consultation with healthcare professionals is advised. There may be an increased risk of genital infections or urinary tract infections, so early treatment should be sought if infection symptoms develop. Due to possible fluid loss in the body, dehydration, and hypotension may occur; thus, caution is needed especially for elderly patients or those with low blood pressure. Rarely, severe metabolic disorders known as ketoacidosis may occur, so if symptoms such as vomiting, abdominal pain, or difficulty breathing arise, immediate medical attention should be sought. Women who are pregnant or planning to become pregnant should avoid taking this medication, and it should also not be used while breastfeeding. This medication has not been confirmed for safety and efficacy in children under 18 years of age. No specific toxicity has been reported in case of overdose, but if suspected, appropriate treatment should be obtained immediately from a medical institution. This medication should be kept out of the reach of children, and transferring it to another container should be avoided as it may affect its quality. Caution is required when driving or operating machinery due to the risk of hypoglycemia, especially if taking this medication with insulin or sulfonylureas. Diabetic patients should prioritize regular foot care, and care should be taken to prevent wounds or infections on the feet while using this medication. If pain, swelling, or redness occurs around the perineum, it could be a serious infection known as perineal necrotizing fasciitis, and immediate medical attention should be sought. This medication can interact with other medications, so it is important to inform healthcare professionals of all medications being taken and undergo regular evaluations.

Serious side effects

• Hives
• angioedema
• ketoacidosis
• urosepsis
• pyelonephritis
• perineal necrosis
• acute cholecystitis
• autoimmune hepatitis
• gallstones
• acute kidney injury

Mild side effects

• Vulvovaginal candidiasis
• vulvitis
• balanitis
• and other genital infections
• hypoglycemia
• itching
• rash
• increased urination
• dehydration
• hypotension

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. It is best to maintain storage temperatures between 1 and 30 degrees Celsius to preserve the medication's efficacy.

Appearance

Light yellow, biconvex oval film-coated tablet

Package unit

30 tablets/bottle