Polaminofen Injection (Acetaminophen)

Adult administration

Adults weighing 50 kg or more: 4 times a day, 1000 mg per administration as acetaminophen, with a minimum dosing interval of 4 hours. The maximum daily dosage should not exceed 4 grams. For children weighing 33 kg or more but less than 50 kg: For each administration, approximately 15 mg/kg as acetaminophen (1.5 ml/kg of this medication), with a minimum dosing interval of 4 hours. The maximum daily dosage is 60 mg.

Child administration

Children weighing 33 kg (approximately 11 years) or older: For each administration, approximately 15 mg/kg as acetaminophen (1.5 ml/kg of this medication), with a minimum dosing interval of 4 hours. The maximum daily dosage is 60 mg.

This medication may cause overdose due to confusion between milligrams and milliliters during administration, so the dosage must be accurately confirmed and administered carefully. It is advisable to quickly switch to an appropriate oral analgesic when oral administration is possible. Always verify whether acetaminophen is included in other medications to avoid excessive dosage. This medication can cause severe liver damage if the recommended dosage is exceeded, thus patients with liver dysfunction or a history of liver disease should be particularly cautious. Symptoms of liver damage may appear between 2 to 6 days after administration, so if abnormal symptoms occur, immediate consultation with medical personnel is advised. Patients with impaired liver function or those who drink heavily daily should consult a doctor or pharmacist before taking this medication, as the risk of liver damage may increase. If serious skin reactions such as rashes, itching, or hives occur during the use of this medication, discontinue use immediately and inform medical personnel. Patients with allergies to acetaminophen or this medication, peptic ulcers, severe liver, kidney, or heart diseases, and a history of aspirin-induced asthma should not use this medication. Special caution is required when administering this medication to patients with liver impairment, kidney impairment, peptic ulcers, blood abnormalities, bleeding tendencies, heart function abnormalities, history of hypersensitivity, asthmatics, the elderly, children, pregnant or breastfeeding women, and patients on certain medications, chronic alcoholics, and those suffering from malnutrition or dehydration. Rare side effects such as hypotension, shock, increased liver enzymes, decrease in blood cells, neurological disturbances, decreased kidney function, skin rashes may occur with this medication. Pain or burning sensation at the injection site can frequently occur, so caution is advised. This medication may interact with specific drugs, so patients taking other medications should inform their doctor or pharmacist, and dosage adjustments or monitoring may be required. It does not affect the ability to drive or operate machinery, but should not be mixed with other medications. Children and elderly patients should use the minimum dosage and be alert for adverse reactions, especially in cases of high fever where their condition should be carefully monitored. This medication may hide symptoms of infection, so appropriate antibiotic treatment may be required if an infection is suspected. Use of this medication during pregnancy is limited, so it should be administered only after consulting with a doctor, and although a small amount may pass into breast milk, reports of adverse reactions are absent. Patients with severe kidney impairment should use it cautiously by increasing the interval between doses. Overdose can result in symptoms such as nausea, vomiting, loss of appetite, abdominal pain, and in severe cases, liver failure and coma may occur, necessitating immediate hospital visits for detoxification treatment. This medication should not be stored at temperatures above 30 degrees, and refrigeration or freezing should be avoided. Prior to administration, check for foreign substances or discoloration. Unused solutions should be discarded, and it should be used for one-time only.

Serious side effects

Allergic reactions, shock, agranulocytosis, neutropenia, leukopenia, thrombocytopenia, coma, acute renal failure, similar to Stevens-Johnson syndrome reactions, pustular rash, Lyell's syndrome, acute generalized exanthematous pustulosis, toxic epidermal necrolysis, Stevens-Johnson syndrome, fulminant hepatitis, liver necrosis, liver failure, angioedema, anaphylactic shock, anaphylaxis, acute generalized exanthematous pustulosis, and liver damage.

Mild side effects

Fatigue, hypotension, increased liver transaminase concentration, thrombocytopenia, tachycardia, nausea, vomiting, injection site reactions (pain, burning), erythema, flushing, itching, rash, urticaria, maculopapular rash, headache, constipation, sputum, sensory disturbances, dizziness, hemoglobin decrease, urinary disorders, nausea, vomiting, high anion gap metabolic acidosis (HAGMA)

This medication should be stored at room temperature between 1 and 30 degrees and kept in a sealed container to avoid contact with air. This preservation helps maintain the effectiveness of the medication.

Appearance

Colorless or pale yellow transparent liquid injection in a colorless polypropylene vial

Package unit

Domestic Use - 100 milliliters/box