New Aminofen Primix Injection (Acetaminophen)

Adult dosage

Adults weighing over 50 kg should be administered 1000 mg of acetaminophen 4 times a day. The dosing interval is at least 4 hours, and the maximum daily dose should not exceed 4 grams. Children weighing 33 kg or more and adults weighing less than 50 kg should be administered 15 mg/kg (1.5 mL/kg) per dose. The dosing interval is at least 4 hours, and the maximum daily dose should not exceed 60 mg/kg or 4 grams.

Children's dosage

Children weighing 10 kg to less than 33 kg (aged 2 years to under 11 years) should be administered 15 mg/kg (1.5 mL/kg) per dose. The dosing interval is at least 4 hours, and the maximum daily dose is 60 mg.

This medication carries a risk of overdose due to confusion between milligrams and milliliters during administration; therefore, the exact dosage must be verified. It is advisable to transition to an appropriate oral analgesic as soon as it is possible. Ensure to check if acetaminophen is included in other medications to avoid excessive intake. Exceeding the recommended dose can lead to serious liver damage, necessitating caution. Symptoms of liver damage usually appear between 4 to 6 days after administration, and rapid detoxification treatment is required. Patients with liver dysfunction must consult a physician before use and should undergo regular liver function tests if using high doses for an extended period. Individuals who consume multiple alcoholic beverages daily should consult a specialist before taking this medication; otherwise, liver damage may occur. Very rarely, serious skin reactions may occur, and if a rash or allergic symptoms appear, the medication should be stopped immediately. Patients with allergies to acetaminophen or this medication, as well as those with peptic ulcers, severe liver or kidney dysfunction, and severe blood disorders should not take this medication. Caution should be exercised for patients with liver or kidney dysfunction, elderly patients, pregnant women, nursing mothers, and patients on certain medications. This medication should not be mixed with other drugs, and children and elderly patients should use the minimum dose and be monitored for adverse reactions. Symptoms such as vomiting, abdominal pain, loss of appetite, etc., may occur in case of overdose, which can progress to severe liver failure or coma, requiring immediate medical attention. During pregnancy, the benefits and risks of this medication should be carefully evaluated before use, and it can be safely used while breastfeeding. This medication is primarily metabolized in the liver and excreted through urine; therefore, dosage adjustments may be necessary for patients with liver or kidney dysfunction. There may be interactions with other medications while taking this medication, so it is essential to inform healthcare professionals of any other medications being taken. When storing, keep in a sealed container at a cool place below 30 degrees Celsius, avoiding refrigeration or freezing. Before administration, check for impurities or discoloration; as this is a single-use medication, any remaining solution should be discarded.

Serious side effects

Urticaria, severe swelling (edema), anaphylactic shock, anaphylaxis, acute generalized exanthematous pustulosis, toxic epidermal necrolysis, Stevens-Johnson syndrome, angioedema, fulminant hepatitis, liver necrosis, liver failure, acute kidney failure, agranulocytosis, neutropenia, leukopenia, thrombocytopenia, shock, coma, acute liver failure

Mild side effects

• Abdominal pain
• fatigue
• low blood pressure
• increased liver transaminase levels
• neurological disorders
• maculopapular rash
• injection site reactions
• erythema
• flushing
• itching

This medication should be stored at room temperature between 1 and 30 degrees Celsius, and it is essential to keep it in a sealed container to prevent air or moisture from entering. Proper storage will help maintain the effectiveness of the medication for a longer period.

Appearance

Clear, light yellow, transparent liquid filled in a colorless and transparent plastic container for injection

Package unit

50 milliliters/bag, 65 milliliters/bag, 75 milliliters/bag, 100 milliliters/bag