Teravial Tablets 100 mg (Sitagliptin Hydrobromide Monohydrate)

Adult dose

This medicine is administered at a dose of 100 mg once a day for monotherapy or combination therapy, with a maximum daily dosage of 100 mg. It can be taken regardless of meals. For patients with renal impairment, administer 50 mg once a day if the glomerular filtration rate is 30–45 mL/min/1.73 m2. For patients with a glomerular filtration rate of 15–30 mL/min/1.73 m2 or those requiring hemodialysis or peritoneal dialysis due to end-stage renal disease, once a day

This medicine may cause serious allergic reactions in some patients; therefore, if symptoms such as rash, hives, difficulty breathing, or swelling of the face or neck occur after use, discontinue the medication immediately and consult a physician. During the use of this medicine, symptoms of pancreatitis, inflammation of the pancreas, may occur; rapid medical attention should be sought if abdominal pain, vomiting, or loss of appetite occurs. This medicine should not be used in patients with type 1 diabetes or diabetic ketoacidosis, nor in patients with an allergy to this medicine or its ingredients. Patients with reduced kidney function may experience delayed excretion of this medicine, so the dosage may need adjustment by a physician, and kidney status should be checked. In clinical trials, side effects such as upper respiratory tract infections, pharyngitis, headache, etc. were primarily reported, and caution is needed as hypoglycemic symptoms can occur when taking it in conjunction with other anti-diabetic medications. The risk of hypoglycemia may increase when this medicine is taken in conjunction with insulin or sulfonylureas, which can induce hypoglycemia, so blood sugar levels should be checked frequently, and dosage adjustments may be necessary. If severe joint pain or blistering symptoms occur during drug intake, consult a doctor immediately to decide whether to discontinue the medication. Pregnant or breastfeeding women should avoid taking this medicine as its safety has not been established. Elderly patients may have decreased kidney function, so it is important to conduct kidney function tests before use and adjust the dosage according to the doctor's instructions. In case of overdose, seek medical attention immediately for appropriate treatment, as this medicine can be partially removed through hemodialysis, which may be considered if necessary. This medicine tends to have fewer interactions with other medications, but certain drug interactions may lead to changes in blood concentration; hence, all currently taken medications should be disclosed to the physician.

Serious side effects

Hives, severe swelling (angioedema), rash, anaphylaxis, exfoliative skin disorders (including Stevens-Johnson syndrome), acute pancreatitis, cardiac arrest, severe and disabling joint pain, bullous pemphigoid, jaundice, acute renal failure, pneumonia, diabetes complications, metabolic acidosis, respiratory distress, severe neurological symptoms, severe hypoglycemia

Mild side effects

• Pharyngitis
• upper respiratory infections
• headache
• diarrhea
• nausea
• abdominal pain
• constipation
• vomiting
• muscle pain
• limb pain

This medicine should be stored in a tightly sealed container to prevent air or moisture ingress, preferably at a temperature between 1 and 30 degrees Celsius room temperature. Storing it this way helps maintain the efficacy and prevent degradation of the medicine.

Appearance

Bright brown, round, bilaterally convex film-coated tablets

Package unit

28 tablets/PTP [(14 tablets/PTP x 2)]