Terabia Tablet 25 mg (Sitagliptin Hydrochloride Monohydrate)

Adult dose

The recommended dosage is 100 mg once daily, whether administered alone or in combination therapy, with a maximum daily dose of 100 mg. It can be taken without regard to meals. For patients with renal impairment, dosage adjustment is necessary based on kidney function. For mild renal impairment (eGFR 60–90 mL/min/1.73 m2) and moderate renal impairment (eGFR 45–60 mL/min/1.73 m2), no dosage adjustment is necessary.

This medication can cause severe allergic reactions; if symptoms such as skin rash or difficulty breathing occur after administration, discontinue use immediately and consult a physician. During treatment, serious pancreatic inflammation known as pancreatitis may occur, so report any symptoms such as abdominal pain or vomiting to healthcare personnel immediately. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, nor in those allergic to this drug or any of its ingredients. Patients with impaired kidney function need dosage adjustments, so regular kidney function tests should be performed and taken as directed by a physician. In clinical trials, this drug showed a side effect profile similar to other blood glucose-lowering agents, but caution is advised as hypoglycemia may occur. When taken with insulin or sulfonylureas, the risk of hypoglycemia may increase, thus dosage adjustments may be necessary. Long-term use may result in headaches, upper respiratory infections, pharyngitis, peripheral edema, etc., and if symptoms are severe, consultation with a physician is recommended. This medication is not recommended for pregnant women and should be avoided by breastfeeding women. Its safety and efficacy in children and adolescents under 18 years have not been established, so use is advised against. When administering to the elderly, dosage should be carefully considered due to the potential for decreased kidney function. In case of overdose, standard symptomatic treatment is performed, and blood dialysis may be necessary to remove the drug if required. If symptoms such as joint pain or skin blisters occur during treatment, notify a physician immediately, and discontinue the medication in severe cases. There are few drug interactions with this medication, but blood levels should be monitored when taking drugs such as digoxin. It is important to consult healthcare personnel immediately if unusual symptoms occur during treatment to receive appropriate care.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, severe rash, skin peeling (exfoliative skin disease, Stevens-Johnson syndrome), pain in mucous membranes of the mouth/eyes, shortness of breath or breathing difficulties, acute pancreatitis (fatal/non-fatal hemorrhagic or necrotizing pancreatitis), sudden and severe headaches, severe and disabling joint pain, blistering similar to pemphigus, elevated liver enzymes, jaundice, acute kidney failure, pneumonia, cardiac arrest

Mild side effects

• Upper respiratory infections
• pharyngitis
• constipation
• vomiting
• headache
• muscle pain
• limb pain
• back pain
• pruritus
• thrombocytopenia

This medication should be stored in an airtight container and kept at room temperature between 1 and 30 degrees Celsius. Storing it this way will maintain the medication's effectiveness and prevent degradation.

Appearance

Pink, round, biconvex, film-coated tablet

Package unit

28 Tablets/PTP [(14 Tablets/PTP x 2)]