Trucita Tablets 25 mg (Sitagliptin hydrochloride monohydrate)

Adult dosage

This medication is administered once daily at a dose of 100 mg for monotherapy or combination therapy, with a maximum daily dose of 100 mg. In patients with renal impairment, dosage adjustment is necessary depending on renal function. - For mild and moderate renal impairment (eGFR 45 to < 90), no dosage adjustment is needed. - For moderate renal impairment (eGFR 30 to < 45), administer 50 mg once daily. - For severe renal impairment or

This medication may cause severe allergic reactions, so if symptoms such as skin rash or swelling occur, discontinue use immediately and consult a doctor. During the use of this medication, symptoms of pancreatitis, an inflammation of the pancreas, may appear; if abdominal pain or vomiting worsens, inform healthcare professionals immediately. It should not be used in patients with type 1 diabetes or diabetic ketoacidosis, nor should it be taken if there is an allergy to this medication or its components. Patients with reduced kidney function need to adjust the dosage of this medication, so appropriate dosing should be determined through renal function tests. Patients in clinical trials taking this medication experienced symptoms such as nasopharyngitis, upper respiratory infections, headaches, and diarrhea compared to a placebo, with an increased risk of hypoglycemia especially when taken with insulin or sulfonylureas. During the use of this medication, severe joint pain or the development of blisters on the skin may occur; if these symptoms appear, notify a doctor immediately. There is a risk of hypoglycemia when taking this medication with other hypoglycemic agents, so it may be necessary to adjust the doses of insulin or sulfonylureas. Pregnant or breastfeeding women should avoid using this medication, and safety in pediatric patients under 18 years of age has not been established. Older adults may have decreased kidney function, so it is important to periodically monitor renal function before and during use. In cases of overdose, some drugs may be removed through hemodialysis, and general emergency treatment should be provided. No major interactions have been reported when this medication is taken with other medications; however, monitoring of blood concentration is necessary when taken with digoxin. If abnormal symptoms appear during the use of this medication, it is important to consult healthcare professionals immediately to receive appropriate action.

Serious side effects

Urticaria, severe swelling (angioedema), anaphylaxis, severe allergic reactions, severe skin adverse reactions (Stevens-Johnson syndrome, exfoliative dermatitis), acute pancreatitis (including fatal/non-fatal hemorrhagic or necrotizing pancreatitis), acute renal failure, severe arthralgia with disability, bullous pemphigoid, rhabdomyolysis, jaundice (associated with elevated liver enzyme levels), severe hypoglycemia

Mild side effects

• Nasopharyngitis
• upper respiratory infection
• headache
• diarrhea
• nausea
• constipation
• myalgia
• limb pain
• back pain
• pruritus

This medication should be stored in a sealed container to prevent air or moisture from entering. The appropriate storage temperature is room temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness for a longer period.

Appearance

Pink round biconvex film-coated tablets

Package unit

PTP - 28 tablets per box [(14 tablets/PTP × 2)]