Neosita Tablet 50 mg (Sitagliptin Hydrochloride Hydrate)

Adult dose

This medication is administered once daily at a dosage of 100 mg, either as monotherapy or in combination therapy, with a maximum daily dosage of 100 mg. It can be taken regardless of meals. Dosage adjustments are necessary based on kidney function. - Patients with mild to moderate renal impairment (eGFR ≥ 45 mL/min/1.73 m2) do not require dosage adjustments. - Patients with moderate renal impairment (eGFR ≥ 30 and < 45 mL/min/1.73 m2) require dosage adjustments.

This medication may cause severe allergic reactions after administration; thus, if symptoms such as skin rash, difficulty breathing, or swelling of the face or neck develop, discontinue use immediately and consult a doctor. Acute pancreatitis, a serious inflammation of the pancreas, may occur. If symptoms such as abdominal pain, vomiting, or severe abdominal discomfort appear, seek medical attention immediately. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis. Patients who have had an allergic reaction to this medication or its components should avoid its use. Patients with reduced kidney function may experience slower excretion of this medication, and dosage adjustment should be made according to a doctor's guidance with regular kidney function tests. Commonly reported side effects in clinical trials include upper respiratory tract infections, nasopharyngitis, headaches, and diarrhea. Hypoglycemic symptoms may also occur, so blood sugar management should be carefully monitored. When taken with insulin or sulfonylurea, the risk of hypoglycemia may increase, requiring dosage adjustments of these medications. Severe joint pain may occur; consider consulting a doctor about discontinuing medication if joint pain worsens. If symptoms such as skin blisters or ulceration appear, notify a doctor immediately for appropriate diagnosis and treatment. The safety of this medication in pregnant women has not been established, so its use is not recommended. Nursing mothers are also advised not to take this medication. Safety has not been confirmed in children and adolescents, so it should not be used in patients under 18 years of age. Elderly patients may have a risk of reduced kidney function, so dosage adjustment and monitoring of kidney function are necessary. In cases of overdose, general symptomatic treatment should be administered, and hemodialysis may be used to remove some of the medication if necessary. This medication generally has no significant drug interactions when used in conjunction with other diabetes medications or cardiovascular drugs, but it is important to consult a doctor or pharmacist about any other medications being taken.

Serious side effects

Urticaria, angioedema, anaphylaxis, exfoliative skin disorders including Stevens-Johnson syndrome, acute pancreatitis, severe and disabling arthralgia, bullous pemphigoid, acute renal failure, elevated liver enzymes, liver abnormalities (jaundice), thrombocytopenia, rhabdomyolysis, cardiac arrest, severe allergic reactions, severe skin adverse reactions, severe neurological symptoms

Mild side effects

• Upper respiratory tract infections
• nasopharyngitis
• headaches
• nausea
• diarrhea
• constipation
• myalgia
• limb pain
• back pain
• dyspepsia

This medication should be stored in a tightly sealed container to prevent air or moisture from entering, and it is recommended to keep it at room temperature between 1°C and 30°C. Proper storage will maintain the effectiveness and safety of the medication.

Appearance

A film-coated tablet that is light apricot in color with a round shape and both sides being convex.

Package unit

28 tablets/box [(14 tablets/PTPX2)]