Yushita Tablets 50 mg (Sitagliptin Hydrochloride Hydrate)

Adult dose

This medication is administered once daily at 100 mg for both monotherapy and combination therapy, with a maximum daily dosage of 100 mg. It can be taken regardless of meals. For patients with renal impairment, dosage adjustments are necessary. - Mild and moderate renal impairment (eGFR 45 or greater and less than 90) do not require dosage adjustments. - For moderate renal impairment (glomerular filtration rate 30 to less than 45), a dosage of 50 mg once daily is to be administered.

This medication can rarely cause serious allergic reactions, so if symptoms such as skin rash, hives, or difficulty breathing occur after administration, use should be discontinued immediately and medical advice should be sought. This medication may cause inflammation of the pancreas; therefore, if symptoms such as abdominal pain, vomiting, or persistent nausea occur, consult a physician immediately. Patients with type 1 diabetes or diabetic ketoacidosis should not use this medication, and it should also not be administered if there is an allergy to this medication or its components. Patients with decreased kidney function need dosage adjustments; therefore, regular kidney function tests should be conducted during treatment. Symptoms of hypoglycemia may appear while taking this medication; thus, particularly when used alongside insulin or sulfonylureas, frequent monitoring of blood glucose levels and precautions against hypoglycemia are advised. This medication can rarely cause side effects such as joint pain or blistering skin disorders; therefore, if severe joint pain or blisters appear on the skin, inform a physician immediately. Women who are pregnant or breastfeeding are advised not to take this medication, and safety and efficacy have not been established in children and adolescents under 18 years of age. In the event of overdosing, the medication should be removed from the gastrointestinal tract and appropriate monitoring, such as ECG tests, should be done; some medications may be removed by hemodialysis if necessary. This medication has relatively low drug interactions when used in combination with other diabetes treatments, but dosage adjustments might be necessary if taken with certain medications; consultation with a physician is recommended. Older adults may have decreased kidney function, so it is essential to assess kidney function before administration and adjust the dose accordingly.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, anaphylaxis, Stevens-Johnson syndrome and exfoliative dermatitis, severe rash with fever, blistering, skin peeling, oral/eye mucosal pain, acute pancreatitis, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of the skin or eyes (jaundice), elevated liver enzymes, extreme lethargy, sudden and

Mild side effects

• Upper respiratory infection
• pharyngitis
• headache
• constipation
• vomiting
• muscle pain
• limb pain
• back pain
• pruritus
• thrombocytopenia

This medication should be stored in a tightly sealed container to prevent exposure to air and kept at room temperature between 1 to 30 degrees Celsius. This way, the medication's efficacy can be maintained and deterioration can be prevented.

Appearance

Bright apricot-colored, round, double-convex film-coated tablets

Package unit

28 tablets/box [14 tablets/PTP x 2]