Lipiduet Tablet 10/10 mg (Ezetimibe, Atorvastatin Calcium Trihydrate)

Adult dosage

This medication is administered once daily regardless of meals. For primary hypercholesterolemia, the daily dose range is between 10/10 mg to 10/80 mg, with a recommended initial dose of 10/10 mg or 10/20 mg once daily. For patients requiring a significant reduction in LDL cholesterol, an initial dose of 10/40 mg once daily is recommended. Blood lipid levels should be checked at least two weeks after starting or adjusting the dosage to determine the need for further adjustments.

This medication may cause muscle abnormalities, leading to severe muscle pain or weakness, which can risk renal function. Patients at high risk of renal damage due to serious infections, surgery, trauma, metabolic disorders, etc., should temporarily discontinue or stop the medication. Patients with allergies to any components of this drug, liver diseases or significantly elevated liver function tests, muscle disorders, pregnant or breastfeeding women, those taking certain antiviral drugs, and lactose intolerant individuals should not take this medication. Caution is advised for individuals with a history of alcoholism or liver disease, those with severe liver dysfunction, decreased renal function, hypothyroidism, family history of muscle disorders, and patients with muscle toxicity reactions to statins or fibrates, individuals over 70 years old, and those taking other medications that may interact with this drug. This medication may cause side effects such as myalgia, abdominal pain, and elevated liver enzymes, and serious skin reactions or allergic responses may arise, necessitating immediate consultation with a physician if unusual symptoms occur. Liver function tests should be performed before starting this medication and regularly during treatment; if signs of liver damage are present, the administration should be discontinued. This drug is not administered to pregnant women or women who may become pregnant, and those taking it should employ appropriate contraception. Moreover, caution is warranted as dizziness may occur when driving or operating machinery. This medication may interact with other drugs, so it is essential to inform the physician or pharmacist of any other medications being taken. There are no specific antidotes for overdose; symptomatic treatment and supportive care while monitoring liver function and muscle enzyme levels are required. It is not recommended for children due to lack of established safety and efficacy.

Serious side effects

Urticaria, serious swelling (including angioedema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, markedly reduced urine output, severe swelling throughout the body with hypertension.

Mild side effects

• Myalgia
• abdominal pain
• elevated liver enzymes
• dizziness
• cough
• nausea
• vomiting
• diarrhea
• arthralgia
• musculoskeletal pain

Store this medication in a tightly closed container to prevent exposure to air or moisture. It is advisable to maintain a storage temperature between 1 and 30 degrees Celsius room temperature.

Appearance

A film-coated tablet shaped like a capsule, convex on both sides, white or light yellow.

Package unit

30 tablets/box [10 tablets/Alu-Alu x 3]