Duophito Tablet 10/20 mg

Adult dosage

This medication is taken once daily, regardless of meals. For primary hypercholesterolemia, the initial dose is recommended to be 10/10 mg or 10/20 mg once daily. For patients requiring a larger reduction in LDL-cholesterol (over 55%), 10/40 mg once daily is recommended. After initiation of treatment or dosage adjustment, blood lipid levels should be checked at intervals of more than two weeks to adjust the dosage.

This medication may rarely cause muscle damage, resulting in severe muscle pain or weakness, which can pose a risk to kidney function. In particular, the medication should be temporarily discontinued or halted in patients with acute infections, hypotension, major surgery or trauma, severe metabolic or electrolyte abnormalities, or poorly controlled seizures. It should not be administered to patients with known allergies to its components, severe liver dysfunction, persistent unexplained liver enzyme elevations, muscle diseases, pregnant or potentially pregnant women, breastfeeding women, patients taking certain antiviral medications, or patients with genetic issues such as lactose intolerance. Caution is advised when prescribing this medication to patients with a history of alcohol addiction or liver disease, renal impairment, hypothyroidism, family history of muscle disease, or previous experiences of muscle toxicity with similar drugs, as well as in the elderly over 70 years of age, and those taking medications that may increase the blood concentration of this drug. This medication may cause side effects such as muscle pain, abdominal pain, increased liver enzymes, and rarely serious muscle damage or liver dysfunction, as well as skin reactions. Patients should report any symptoms such as muscle pain, muscle weakness, fatigue, or fever immediately to their healthcare provider for assessment. Regular liver function and muscle enzyme tests should be conducted while on this medication, and any abnormal findings should prompt consideration of dose adjustments or discontinuation. Furthermore, alcohol consumption should be avoided during treatment, and special care should be taken for those with a history of liver disease. Pregnant or breastfeeding women should not take this medication, and women of childbearing age should use suitable contraception while on this medication. This medication may interact with other drugs, so patients should inform their healthcare provider of any other medications they are taking, especially certain antibiotics, antivirals, antifungals, and immunosuppressants. In case of overdose, there is no specific antidote, and treatment should be symptomatic while monitoring liver function and muscle enzyme levels. Safety in children or adolescents has not been established, so this medication is not recommended for them. Elderly patients should be cautious due to the risk of myopathy; however, no separate dose adjustment is necessary. This medication should be kept out of reach of children and should not be transferred to another container.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash accompanied by high fever, blisters, skin peeling, pain in oral/eye mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory issues accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, and urination.

Mild side effects

• Muscle pain
• abdominal pain
• increased liver enzymes
• dizziness
• cough
• nausea
• diarrhea
• joint pain
• muscle weakness
• musculoskeletal pain

This medication should be stored in a tightly closed container to avoid exposure to air or moisture, preferably in a cool place below 30 degrees Celsius. Proper storage maintains the drug's effectiveness and prevents degradation.

Appearance

White to off-white, biconvex, oval film-coated tablet

Package unit

30 tablets/box [10 tablets/PVC×3]