Jintozet Tablet 10/40 mg

Adult dosage

This drug is taken once daily, regardless of meals. For primary hypercholesterolemia, the dosage range is 10/10 mg to 10/80 mg daily, with an initial recommended dosage of 10/10 mg or 10/20 mg daily. For patients requiring a greater reduction in LDL cholesterol (55% or more), an initial dose of 10/40 mg daily is recommended. After starting treatment or adjusting the dosage, lipid levels should be checked at intervals of more than 2 weeks.

This drug has been reported to cause a rare side effect called rhabdomyolysis, which can lead to severe muscle damage. In particular, patients with acute infections, hypotension, major surgery, trauma, severe metabolic disorders, endocrine problems, or uncontrolled seizures should temporarily discontinue or stop this medication. Some patients should not be given this drug if they have allergies to the active ingredients or components, active liver disease or unexplained increases in liver enzymes, muscle disorders, are pregnant or possibly pregnant, breastfeeding, taking certain antiviral medications, or have genetic metabolic disorders like lactose intolerance. Patients with caution include alcoholics, patients with moderate to severe liver dysfunction, those with poor kidney function or hypothyroidism, a family or personal history of myopathy, elderly patients over 70 years of age, and those taking specific medications should use this drug cautiously. While taking this drug, side effects such as myalgia, abdominal pain, elevated liver enzymes, dizziness, cough, nausea, joint pain, muscle weakness, musculoskeletal pain, hyperkalemia, bronchitis, sinusitis, flushing, diarrhea, constipation, fatigue, malaise, chest pain, fever, weakness, rhinitis, hyperglycemia, hypoglycemia, weight gain, loss of appetite, indigestion, vomiting, belching, pancreatitis, pharyngeal/laryngeal pain, nosebleeds, insomnia, nightmares, sensory disturbances, numbness, taste disorders, and memory issues may occur, and rarely, serious muscle damage, liver dysfunction, or allergic reactions may develop. Therefore, if any abnormal symptoms occur, consult a physician immediately. Liver function tests must be performed before starting and regularly during treatment to check for liver damage. If liver enzyme levels significantly increase or symptoms of hepatitis appear, the medication should be discontinued. Women who are pregnant or breastfeeding should not take this medication, and fertile women should use adequate contraceptive methods while taking it. Safety and efficacy have not been established for children, so it is not recommended. The elderly need to be cautious due to an increased risk of myopathy, but general dose adjustments are not required. Moreover, this drug can interact with various drugs, so if other medications are being taken, it is essential to inform the doctor or pharmacist, especially when combined with drugs that may increase the risk of muscle damage. In case of overdose, as there is no specific antidote, supportive therapy and treatment according to symptoms should be provided while monitoring liver function and muscle enzyme levels. Finally, keep this medication out of the reach of children and do not transfer it to another container.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities associated with cough+fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, vision abnormalities, paralysis, urination

Mild side effects

• Myalgia
• abdominal pain
• elevated liver enzymes
• dizziness
• cough
• nausea
• arthralgia
• muscle weakness
• musculoskeletal pain
• hyperkalemia

This drug should be stored in a tightly sealed container to prevent air and moisture ingress and kept at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the drug's efficacy and ensure safe use.

Appearance

White rectangular film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP packaging (Alu-Alu)x3], 30 tablets/bottle, 100 tablets/bottle