Sitagliptin 100 mg (Sitagliptin Hydrochloride Monohydrate)

Adult dosage

This medication is administered once daily at a dose of 100 mg, either as monotherapy or in combination therapy, with a maximum daily dose of 100 mg. In patients with renal impairment, no dosage adjustment is needed for mild to moderate renal impairment. For patients with moderate renal impairment (glomerular filtration rate 30-45 mL/min/1.73 m2), the dose is 50 mg once daily. For patients with severe renal impairment (glomerular filtration rate 15-30 mL/min/1.73 m2) or end-stage renal disease requiring dialysis or peritoneal dialysis (glomerular filtration rate < 15 mL/min/1.73 m2), the dose is 25 mg once daily.

This medication can cause severe allergic reactions; therefore, if symptoms such as skin rash, difficulty in breathing, or swelling of the face or neck occur after use, discontinue use immediately and seek medical attention. During the course of this medication, severe inflammation of the pancreas (pancreatitis) may occur, so if symptoms such as abdominal pain, vomiting, or fever develop, notify healthcare personnel immediately. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and should also be avoided by those with a severe allergic reaction to this medication or its components. Patients with decreased kidney function may require dosage adjustments and should undergo regular kidney function tests. During treatment, symptoms similar to cold, headache, dyspepsia, diarrhea, etc. may occur, and hypoglycemic symptoms may also appear, so blood glucose levels should be monitored closely. When taken in combination with insulin or other hypoglycemic agents, the risk of hypoglycemia may increase, so dosage adjustments for hypoglycemic agents may be necessary. This medication is not recommended for use during pregnancy and should be avoided while breastfeeding. The safety and efficacy of this medication have not been fully established in individuals under 18 years of age. Elderly patients are at risk of decreased kidney function, so it is important to evaluate kidney function before administration and to check periodically during treatment. In case of overdose, seek medical help immediately for appropriate treatment; some drugs may be removed by hemodialysis. This medication can interact with certain drugs, therefore be sure to inform healthcare personnel if you are taking other medications. Also, if severe joint pain or blistering skin symptoms occur while taking this medication, consult a doctor immediately.

Serious side effects

Urticaria, severe swelling (angioedema), chest tightness, difficulty breathing, anaphylaxis, exfoliative skin diseases such as Stevens-Johnson syndrome, severe skin adverse reactions, acute pancreatitis, severe allergic reactions, joint pain accompanied by severe symptoms or disability, blistering dermatosis, liver abnormalities (elevated liver enzyme levels), acute renal failure, rhabdomyolysis, serious neurological symptoms are not specified but require caution.

Mild side effects

• Upper respiratory tract infection
• nasopharyngitis
• constipation
• vomiting
• headache
• muscle pain
• limb pain
• back pain
• pruritus
• thrombocytopenia

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture. It is recommended to maintain storage temperature at room temperature between 1 degree and 30 degrees.

Appearance

Light brown, round, bilaterally convex, film-coated tablet

Package unit

28 tablets/box [14 tablets/PTPX2]