Nanubia Tablets 100 milligrams (Sitagliptin Hydrochloride Monohydrate)

Adult dose

The recommended dose for this medication is 100 mg once daily, whether used alone or in combination, with a maximum daily dose of 100 mg. It can be taken irrespective of meals. For patients with renal impairment, the following dosage adjustments are recommended: 1. Mild renal impairment (eGFR 60 to less than 90) does not require dosage adjustment. 2. Moderate renal impairment (eGFR 45 to less than 60) does not require dosage adjustment. 3. Moderate renal impairment (eGFR 30 to 45) requires a dosage of 50 mg once daily.

This medication is a drug that helps patients with diabetes control their blood glucose levels. While taking this medication, serious allergic reactions may occur infrequently. Conditions such as anaphylaxis, angioedema, and severe skin conditions have been reported, so if these symptoms occur, it is essential to stop taking the medication immediately and consult a doctor. Additionally, there is a risk of developing acute pancreatitis, which is inflammation of the pancreas, during treatment. It is crucial to inform healthcare providers immediately if abdominal pain, vomiting, or severe abdominal discomfort occurs. Patients with type 1 diabetes, diabetic ketoacidosis, or a hypersensitivity to this drug or its components should not take this medication. Patients with reduced kidney function may need to adjust dosages, and regular kidney function tests before and during treatment are advisable. In clinical trials, the incidence of hypoglycemia with this drug was similar to or slightly higher than that with placebo when used alone or in combination with other diabetes medications. Care should be taken especially when taken with insulin or sulfonylureas, as there is an increased risk of hypoglycemia. While taking this medication, side effects such as upper respiratory infections, nasopharyngitis, headaches, diarrhea, dyspepsia, etc., may occur. Severe joint pain or blistering skin conditions may occur, so it is necessary to notify a doctor immediately if these symptoms arise, and the medication should be discontinued if needed. Pregnant or breastfeeding women are advised against taking this medication, and safety in children and adolescents under 18 years of age has not been established. This medication has a low potential for drug interactions; however, caution may be required when used in combination with certain medications, so consultation with a physician or pharmacist is recommended. In the case of overdose, general emergency measures should be taken, and this drug can be partially removed by hemodialysis if necessary. Elderly patients may experience decreased kidney function, so dosage adjustments and monitoring of kidney function are necessary. This medication has been shown not to increase cardiovascular risk in cardiovascular safety studies.

Serious side effects

Hives, severe swelling (edema), anaphylaxis, angioedema, severe rashes, exfoliative skin diseases (including Stevens-Johnson syndrome), severe adverse skin reactions, difficulty breathing, pancreatitis, acute pancreatitis, acute renal failure, liver function abnormalities (elevated liver enzyme levels, potential jaundice), sudden and severe headaches, heart failure, cardiac arrest, acute renal function deterioration, severe and disabling joint pain, blistering dermatosis

Mild side effects

• Upper respiratory infections
• nasopharyngitis
• constipation
• vomiting
• headache
• joint pain
• muscle pain
• limb pain
• back pain
• pruritus

Store this medication in a tightly sealed container to prevent air from entering, and keep it at a temperature between 1 and 30 degrees Celsius. Storing it this way helps to maintain the effectiveness of the medicine and prevents degradation.

Appearance

A bright brown, round, biconvex film-coated tablet.

Package unit

28 tablets/box [(14 tablets/PTPX2)]