Nanubia 50 mg Tablet (Sitagliptin Hydrochloride Monohydrate)

Adult dose

This medication can be administered once daily at a dose of 100 mg as either monotherapy or in combination therapy, with a maximum daily dose of 100 mg. It can be taken without regard to meals. For patients with renal impairment, the need for dosage adjustment may vary. - For mild and moderate renal impairment (eGFR 45 or more but less than 90), no dosage adjustment is necessary. - For moderate renal impairment (eGFR 30 or more but less than 45), the dose should be 50 mg once daily.

This medication may cause severe allergic reactions, and if symptoms such as skin rash, difficulty breathing, or swelling of the face or lips occur within three months of starting treatment, it should be discontinued immediately, and a doctor should be consulted. Severe adverse effects like pancreatitis (inflammation of the pancreas) have been reported with this medication, so if symptoms such as abdominal pain, vomiting, or loss of appetite occur while taking this medication, medical advice should be sought immediately. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and should be avoided in patients with hypersensitivity to this medication or any of its components. Patients with impaired kidney function may experience delayed excretion of this medication, thus the dosage should be reduced, and regular kidney function tests are essential. In clinical trials, patients taking this medication experienced side effects similar to colds, upper respiratory infections, headaches, abdominal pain, and diarrhea, and particularly if taken with other blood glucose-lowering agents, hypoglycemic symptoms may occur more frequently. When this medication is taken with insulin or sulfonylurea, the risk of hypoglycemia is increased, so blood glucose should be checked frequently, and the dosage of hypoglycemic agents should be adjusted as needed. If joint pain or skin blisters occur during medication use, consult a doctor immediately, and in severe cases, discontinue the medication. Pregnant or nursing women are advised against using this medication, and consultation with a doctor is mandatory before use. In the case of overdose, the drug should be removed from the gastrointestinal tract, and monitoring of the condition through an electrocardiogram may be performed, and, if necessary, dialysis may be carried out. This medication has relatively low interactions with other drugs, but it is advisable to consult healthcare providers when taking specific medications together. Elderly patients are likely to have decreased kidney function; therefore, dosage adjustment and kidney function testing are necessary when using this medication.

Serious side effects

Urticaria, severe swelling (angioedema), anaphylaxis, Stevens-Johnson syndrome (exfoliative skin disease), severe rash and blisters accompanied by high fever, pain in oral/ocular mucosa, acute pancreatitis, difficulty breathing (respiratory issues), liver abnormalities (jaundice of skin or eyes, general malaise), severe joint pain with disability, bullous pemphigoid, thrombocytopenia, acute renal failure, severe allergic reactions, serious neurological symptoms

Mild side effects

• Nasopharyngitis
• upper respiratory infection
• headache
• constipation
• vomiting
• muscle pain
• limb pain
• back pain
• pruritus
• thrombocytopenia

This medication should be stored in a tightly sealed container to prevent air from entering, and it is recommended to keep it at room temperature between 1 to 30 degrees Celsius. Proper storage will maintain the medication's effectiveness and prevent degradation.

Appearance

Light apricot-colored, round, biconvex film-coated tablet

Package unit

28 tablets/box [(14 tablets/PTP x 2)]