Janus Tablet 100 mg (Sitagliptin Phosphate Hydrate)

Adult dosage

This medication is administered as 100 mg once daily for either monotherapy or combination therapy, with a maximum daily dosage of 100 mg. It can be taken regardless of meals. For patients with renal impairment, 1. In patients with mild renal impairment (eGFR ≥ 60 and < 90), dosage adjustment is not necessary. 2. In patients with moderate renal impairment (eGFR ≥ 45 and < 60), dosage adjustment is not necessary. 3. In patients with moderate renal impairment

This medication may cause severe hypersensitivity reactions after administration; therefore, if any allergic symptoms or skin abnormalities occur, use should be discontinued immediately, and a physician should be consulted. Additionally, this medication may induce severe pancreatic conditions such as pancreatitis, so if symptoms like abdominal pain, vomiting, or appetite loss arise, it should be discontinued immediately and medical personnel should be notified. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and it should not be administered in cases of allergy to this medication or its components. Patients with impaired renal function should have their dosage adjusted; regular renal function tests should be obtained, and administration should be conducted under medical supervision. This medication can increase the risk of hypoglycemia when used with other glucose-lowering medications, especially insulin or sulfonylureas, so attention should be paid to symptoms of hypoglycemia, with dosage adjustments made as needed. Side effects such as headache, upper respiratory infections, nasopharyngitis, diarrhea, etc., may occur during treatment; if these symptoms are severe or persistent, consult a physician. In cases of severe arthralgia or skin blistering, medication should be stopped immediately, and specialized medical attention should be sought. Pregnant or breastfeeding women are advised not to use this medication, and safety in children and adolescents under 18 years has not been established. Elderly patients may have a risk of reduced renal function, necessitating dosage adjustments and regular renal function tests. In cases of overdose, general treatment along with ECG monitoring is necessary as some may be removed by hemodialysis, so this should be considered if needed. This medication has a relatively low interaction with other drugs; however, caution is necessary when taking specific medications, hence all medications should be disclosed to medical personnel. Finally, while this medication does not majorly affect cardiovascular safety, immediate consultation with medical personnel is necessary if any abnormal symptoms occur during use.

Serious side effects

Urticaria, severe swelling (angioedema), anaphylaxis, rash, chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rash, blistering, skin peeling, oral/ocular mucosal pain, severe skin reactions, sudden and very severe headache, thunderclap headache, seizure, altered consciousness, vision changes, paralysis, severe neurological symptoms, significantly decreased urine output, generalized severe swelling and increased blood pressure

Mild side effects

• Hypoglycemia
• upper respiratory infections
• nasopharyngitis
• headache
• diarrhea
• nausea
• constipation
• myalgia
• limb pain
• back pain

This medication should be stored in a tightly closed container to prevent air or moisture from entering. It is recommended to maintain the storage temperature between 1 to 30 degrees Celsius.

Appearance

Beige round biconvex film-coated tablets

Package unit

30 tablets/bottle, 90 tablets/bottle