Lipisrim Capsule 60 mg (Orlistat)

Adult dose

The recommended dose is 120 mg of orlistat per dose, taken orally 3 times daily with a fat-containing meal or within 1 hour after a meal. Patients should continue a nutritionally balanced, mildly calorie-restricted diet in which approximately 30 % of calories are derived from fat. Daily intake of fat, carbohydrates, and protein should be distributed evenly among the three meals. This medicine may be omitted if a meal is skipped or if the meal contains no fat. Because this medicine may reduce the absorption of some fat-soluble vitamins and beta-carotene, patients are advised to take a multivitamin containing fat-soluble vitamins to ensure adequate nutritional intake. The vitamin supplement should be taken at least 2 hours before this medicine or at least 2 hours after it, such as at bedtime. Taking more than 120 mg per dose 3 times daily does not increase the effectiveness of this medicine. Based on measurements of fecal fat, the effect of this medicine appears 24 ∼ 48 hours after taking it. After treatment is discontinued, fecal fat content generally returns to pretreatment levels within 48 ∼ 72 hours. The efficacy and safety of this medicine have not been evaluated for periods exceeding 4 years. Studies have not been conducted in patients with hepatic and/or renal impairment or in elderly patients.

Child dose

Studies have not been conducted in children under 12 years of age.

This medication should not be used by individuals with chronic malabsorption syndrome or cholestasis. Individuals allergic to this drug or its ingredients, pregnant women, women who may become pregnant, and nursing mothers should also avoid using this medication. Liver damage has been rarely reported; therefore, if there are signs of liver dysfunction, notify a doctor immediately and discontinue use. It is important to check liver enzyme levels through liver function tests. Additionally, patients with hyperoxaluria or calcium oxalate kidney stones should use this medication cautiously. This medication may lead to gastrointestinal adverse reactions more frequently than a placebo, primarily including abdominal pain, abdominal distension, flatulence, constipation, and oily stools. These symptoms are usually mild and transient, occurring within 3 months and improving within 4 weeks. However, in some patients, they may persist for more than 6 months. There could be instances where treatment is discontinued due to adverse reactions from this medication, primarily due to gastrointestinal side effects. Rarely, hypersensitivity reactions such as hepatitis and anaphylaxis have been reported. When taken with a high-fat meal, gastrointestinal adverse reactions may increase, so dietary guidelines should be followed to control fat intake and distribute it evenly across three meals. Furthermore, this medication can decrease the absorption of fat-soluble vitamins and beta-carotene; therefore, it is recommended to take a multivitamin supplement, and it should be taken at least 2 hours before or after taking this medication. During pregnancy, it is advised not to take this medication, and nursing women should also avoid its use. For children, use is recommended only for adolescents aged 12 years and older, as safety and efficacy have not been established for children under 12 years of age. Due to insufficient clinical data on the elderly, caution is required. This medication may interact with other drugs; therefore, patients who are taking immunosuppressants, anticoagulants, antiepileptics, or antiretrovirals should consult their doctors. Careful monitoring of blood coagulation status is necessary when used in conjunction with oral anticoagulants. In case of overdose, 24-hour observation is needed, and serious adverse reactions are rarely observed. When storing the medication, keep it out of the reach of children, protect it from light and moisture, and maintain it in its original packaging.

• Fatty stools
• abdominal bloating and gas
• increased frequency of stool
• steatorrhea
• increased bowel movements
• fecal incontinence
• abdominal pain/discomfort
• nausea
• infectious diarrhea
• rectal pain/discomfort

This medication is sensitive to air, light, and moisture, so it should be stored in a sealed container. Additionally, it should be kept in a cool place below 25 degrees Celsius to maintain its effectiveness.

Appearance

A hard capsule containing a white or whitish powder or granules, with a yellow hard capsule body.

Package unit

Case - 90 capsules/box [10 capsules/PTP X 9], Bottle - 300 capsules/bottle