Neofenol Tablets 145mg (Fenofibrate)

Adult dose

As Fenofibrate, take 145 mg once daily by mouth, regardless of meals, but always accompany it with dietary therapy. This medication may be less absorbed when taken on an empty stomach, so it should be taken immediately after meals (excluding the 145 mg formulation).

Child dose

There is currently no clinical data regarding the use of this medication in children.

This medication should not be used in patients with impaired liver function. Patients with moderate to severe renal impairment should also refrain from taking this medication, especially in cases where serum creatinine levels exceed 2.5mg/dL. Women who are pregnant or may become pregnant, as well as lactating women, should not take this medication. Patients with a known allergy to this medication or any of its components should avoid its use. Patients with gallbladder disease or gallstone formation, as well as those who have experienced phototoxic reactions to this medication or related drugs, should also refrain from taking it. This medication should not be administered to children. Patients with bile duct cirrhosis or pancreatitis should not use this medication either. Additionally, this medication contains lactose, so patients with lactose intolerance or related genetic disorders should avoid it. Patients with mild renal impairment or a history of such issues should use this medication with caution and may need to reduce the dosage or increase the dosing interval. Patients with liver function abnormalities or a history of liver disease should also be cautious, as liver function test results may vary. Patients with hypoalbuminemia, a history of gallstones, those on anticoagulant medications, and the elderly should carefully consider their use of this medication. Taking this medication may increase liver function test results, and rare instances of severe liver problems such as hepatitis, cholestatic hepatitis, and cirrhosis may occur. Skin rash or itching, photosensitivity reactions may appear, and rare cases of hair loss have been reported. Neurological symptoms such as dizziness, headache, and weakness have also been reported. Musculoskeletal adverse reactions such as thrombosis, myalgia, muscle cramps, and muscle damage may occur, so any symptoms should be discussed with a doctor. In the gastrointestinal system, abdominal pain, nausea, vomiting, and diarrhea are common complaints, and rare cases of pancreatitis have been reported. Rare adverse reactions may occur in several organs, including the respiratory system, blood, and kidneys, so caution is advised. During treatment with this medication, regular monitoring of liver and kidney function, as well as periodic checks of blood lipid concentrations, is necessary. If gallstones are suspected, gallbladder examinations should be conducted, and if gallstones are found, medication treatment should be discontinued. Additionally, this medication may cause hypersensitivity reactions, so if symptoms such as skin rash or breathing difficulties occur, immediate medical attention should be sought. Drug interactions should also be taken into consideration. In particular, combining it with statin-class medications for cholesterol reduction may increase the risk of muscle damage, so co-administration should be avoided or approached with caution. When used concomitantly with anticoagulants, dosage adjustments and regular blood tests are required to minimize bleeding risks. Symptoms of hypoglycemia may manifest when used with antihyperglycemic agents, so blood sugar levels and symptoms should be carefully monitored. Caution is also needed when used in conjunction with urate-lowering agents, oral contraceptives, or medications with hepatotoxic risks. During pregnancy, it should not be used as it poses a risk to the fetus, and lactating women should also avoid it. This medication should not be used in children. The elderly are at higher risk for adverse reactions due to the likelihood of decreased liver and kidney function, so they should be even more cautious. In cases of overdose, there is no specific antidote, so strict adherence to the prescribed dose is necessary, and it should be kept out of reach of children. Transferring the medication to other containers may lead to quality deterioration or accidents, so this should be avoided.

Serious side effects

• Urticaria
• severe swelling (edema)
• skin rash requiring hospitalization
• Stevens-Johnson syndrome
• toxic epidermal necrolysis
• anaphylaxis
• angioedema
• severe rash with fever
• blisters
• skin peeling

Mild side effects

Increased serum aminotransferase levels, liver enlargement, cholestatic hepatitis, gallstones, rash, itching, photosensitivity reactions, hair loss, weakness, fever, dizziness, headaches, peripheral neuropathy, thrombosis (pulmonary embolism, deep vein thrombosis), elevated creatine kinase (CK) levels, myalgia, muscle cramps, joint pain, gastrointestinal disturbances (abdominal pain, nausea, vomiting, diarrhea, abdominal bloating), epileptic seizures, hemoglobin decrease, leukopenia, eosinophilia

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. It is best stored at room temperature between 1 degree and 30 degrees. Proper storage can help maintain the effectiveness of the medication and ensure safe usage.

Appearance

White oval film-coated tablet

Package unit

30 tablets/bottle