Celsita Tablet 100mg (Sitagliptin Hydrochloride Monohydrate)

Adult dose

The usual dose for this medication is 100 mg once daily, either as monotherapy or combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. Dose adjustments for patients with kidney impairment: 1. For mild renal impairment (glomerular filtration rate [eGFR] ≥ 60 and < 90), dose adjustment is not needed. 2. For moderate renal impairment (glomerular filtration rate [eGFR] ≥ 45 and < 60), dose adjustment is not needed. 3. For moderate renal impairment (eGFR continues here)

This medication can cause rare but serious allergic reactions; therefore, if skin rash, difficulty breathing, swelling of the face or neck appear within three months after administration, use should be discontinued immediately, and a doctor consulted. It may cause inflammation of the pancreas (pancreatitis); if severe abdominal pain, vomiting, or fever occur, the medication should be discontinued immediately, and medical attention sought. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, nor in those allergic to the drug or its components. In patients with impaired kidney function, the dose of this medication needs to be adjusted, and it should be taken only under the guidance of a physician. During treatment, symptoms of hypoglycemia may occur; hence, blood sugar levels should be monitored closely, especially when used in conjunction with insulin or sulfonylureas. While taking this medication, headaches, upper respiratory infections, nasopharyngitis, diarrhea, nausea, and other symptoms may occur; if symptoms persist or worsen, consultation with healthcare professionals is advised. If symptoms such as severe joint pain or blistering of the skin occur, the medication should be discontinued immediately and a specialist consulted. Pregnant or breastfeeding women are advised not to use this medication, and its safety and efficacy have not been established for children or adolescents under 18 years of age. In case of overdose, general symptomatic treatment should be conducted, with blood dialysis available to remove some of the drug if necessary, so patients should promptly seek medical attention in emergencies. This medication generally interacts little with other drugs, but it may change blood concentration levels for certain medications; therefore, healthcare providers should be informed of any drugs being taken. Elderly patients may experience decreased kidney function, so regular kidney function tests are recommended, which may require dose adjustments.

Serious side effects

• Hives, angioedema, anaphylaxis, Stevens-Johnson syndrome, and exfoliative skin disorders (severe allergic reactions)
• Severe rashes with high fever, blisters, skin peeling, pain in oral/ocular mucosa (severe skin adverse reactions)
• Acute pancreatitis (including fatal/non-fatal hemorrhagic or necrotizing pancreatitis)
• Acute renal failure (sometimes requires dialysis) (worsening renal function)
• Severe and disabling joint pain
• Bullous pemphigoid
• Pneumonia,

Mild side effects

• Nasopharyngitis
• upper respiratory infections
• headache
• diarrhea
• nausea
• constipation
• vomiting
• muscle pain
• limb pain
• back pain

This medication should be stored in a tightly sealed container to protect it from air and moisture, at a temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication for a longer period.

Appearance

Light orange, round, double-convex film-coated tablets

Package unit

28 tablets (14 tablets/PTP x 2) - 14 tablets/PTP [28 tablets (14 tablets/PTP x 2)], 30 tablets (10 tablets/PTP x 3) - 10 tablets/PTP [30 tablets (10 tablets/PTP x 3)]