Nexgliptin 50 mg (Sitagliptin Hydrochloride Hydrate)

Adult dose

In adults, this medication is administered once daily at a dosage of 100 mg, with a maximum daily dose of 100 mg. For patients with renal impairment, in mild and moderate cases, no dose adjustment is needed. In moderate cases (glomerular filtration rate 30–45 mL/min/1.73 m²), administer 50 mg once daily, and for severe and end-stage renal impairment patients, 25 mg once daily. This medication can be taken regardless of meals.

This medication may cause allergic reactions; if symptoms such as skin rash or difficulty breathing occur after taking the medication, discontinue use immediately and consult a doctor. This medication may cause severe inflammation of the pancreas known as pancreatitis, so if abdominal pain, nausea, or vomiting occurs while taking it, seek medical attention immediately. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis. Patients with impaired kidney function may need dosing adjustments, and should follow the doctor's instructions based on kidney function test results. Be cautious of hypoglycemic symptoms while taking this medication, especially when used in combination with other hypoglycemic agents like insulin or sulfonylureas, as the risk of hypoglycemia may be increased. Side effects such as headaches, upper respiratory infections, nasopharyngitis, diarrhea, nausea, abdominal pain, constipation, vomiting, muscle pain, limb pain, back pain, pruritus, thrombocytopenia, dyspepsia, dizziness, increased triglycerides, increased low-density lipoprotein, hyperglycemia, hypertension, weight loss, erectile dysfunction, and elevated liver enzymes may occur, so if symptoms persist or worsen, consult a doctor. Pregnant or breastfeeding women should avoid taking this medication, and safety in children under 18 has not been established. Older adults may have decreased kidney function, so it is important to regularly monitor kidney function before and after taking the medication. In cases of overdose, treatment may be necessary to remove the drug from the gastrointestinal tract and monitor the condition through electrocardiograms, and some drugs may be removed through hemodialysis. This medication generally has few interactions with specific drugs, but inform your doctor or pharmacist if you are taking other medications. If severe joint pain or skin blisters occur while taking this medication, inform your doctor immediately and discontinue use.

Serious side effects

Hypersensitivity reactions (anaphylaxis, angioedema, urticaria), Stevens-Johnson syndrome and exfoliative skin diseases, acute pancreatitis (including fatal/non-fatal hemorrhagic or necrotizing forms), acute renal failure, severe and disabling joint pain, blistering pemphigoid, hepatic abnormalities (including elevated liver enzymes), severe allergic reactions (such as chest tightness, difficulty breathing), severe skin reactions (severe rash, blisters, skin peeling).

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• headache
• diarrhea
• nausea
• abdominal pain
• constipation
• vomiting
• muscle pain
• limb pain

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture, ideally at room temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness.

Appearance

Pale yellow-pink round, biconvex film-coated tablet

Package unit

30 tablets - 10 tablets per PTPy [x3]