Siglib 100 mg (Sitagliptin Hydrochloride Hydrate)

Adult dose

This drug is administered at a dosage of 100 mg once daily for either monotherapy or combination therapy, with a maximum daily dosage of 100 mg. It can be taken regardless of meals. For patients with renal impairment, dosage adjustments are necessary based on renal function. - Mild renal impairment (eGFR 60-90 mL/min/1.73 m2): No dosage adjustment required - Moderate renal impairment (eGFR 45-60 mL/min/1.73 m2): Dosage adjustment required

This medication may cause severe allergic reactions after administration, so if symptoms such as skin rash, difficulty breathing, or swelling of the face or neck occur, use should be discontinued immediately and consult a physician. Moreover, this drug may cause serious inflammation of the pancreas called pancreatitis, so if symptoms such as abdominal pain, vomiting, or loss of appetite occur, notify medical personnel immediately. This drug should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and should not be administered to patients who have an allergy to this drug or its components. Patients with impaired kidney function may have the drug stay in their body for a prolonged period, so dosage adjustments are required, and it is important to undergo regular kidney function testing. When taking this drug, caution should be exercised regarding symptoms of hypoglycemia, and particularly when taken with insulin or sulfonylureas, the risk of hypoglycemia may increase, thus frequent blood sugar checks are necessary. If severe joint pain or skin blistering symptoms appear, consult a physician immediately, and the use of this medication can be discontinued if necessary. Women who are pregnant or nursing are advised not to take this medication, and safety for children or adolescents under 18 has not been established. This medication does not show significant interactions when taken together with other diabetes treatments or certain medications; however, caution may be required when combined with specific drugs, so consult medical personnel. In cases of overdose, measures should be taken to remove the drug from the gastrointestinal tract and monitor the condition using an electrocardiogram, and blood dialysis may be considered if necessary. Lastly, in elderly patients, dosage should be determined carefully considering the possibility of reduced kidney function, and it is recommended to regularly evaluate kidney function.

Serious side effects

Urticaria, angioedema, anaphylaxis, Stevens-Johnson syndrome, exfoliative skin disease, acute pancreatitis, skin rash, blisters, pain in mucous membranes of the mouth/eyes, acute renal failure, joint pain accompanied by severe symptoms and disabilities, blistering similar to pemphigus, rhabdomyolysis, pneumonia, diabetic complications, metabolic acidosis, falls, cardiac arrest

Mild side effects

• Pharyngitis
• upper respiratory tract infection
• headache
• diarrhea
• nausea
• constipation
• myalgia
• limb pain
• back pain
• pruritus

This medication should be stored in a tightly sealed container to prevent air or moisture infiltration, maintaining the storage temperature between 1 and 30 degrees Celsius. By storing it this way, the efficacy of the medication can be preserved for a long time.

Appearance

Light orange, round, biconvex film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]