HyuRions Injection 200 IU/mL (Sodium Heparin)

Adult dosage

Typically, after administration of this medication, the whole blood coagulation time (Lee-White method) or whole blood activated partial thromboplastin time (WBAPTT) is adjusted to be 2-3 times normal, depending on age and symptoms. For extracorporeal circulation (hemodialysis), administer between 1,000 to 5,000 units based on each patient's heparin sensitivity test result before dialysis, and continuously administer 500 to 1,500 units per hour or intermittently after starting dialysis.

This medication is a very potent drug and must be used only under the strict supervision of a physician. Special precautions should be taken when administering to patients with diseases that have a high risk of bleeding, as bleeding can occur in various parts of the body in those receiving this medication. It should not be administered to patients who have hypersensitivity to this drug, those with inappropriate results from blood coagulation tests, patients with existing bleeding issues, severe liver or kidney disease, etc. Caution is also required for patients who have recently undergone surgery or trauma, or those who have received spinal or epidural anesthesia. During use, blood coagulation ability tests and platelet counts should be checked regularly to detect and respond to side effects such as bleeding or thrombocytopenia early. If severe thrombocytopenia occurs, administration should be stopped immediately, and alternative anticoagulants should be used if necessary. This medication may interact with various drugs; extra caution is needed when used in conjunction with pain relievers, anti-inflammatory drugs, and anticoagulants. Women who are pregnant or may become pregnant should be particularly cautious due to the risk of uterine and placental bleeding, and careful management is required during delivery. Elderly patients and children may have an increased risk of bleeding, requiring extra caution during administration. In the case of overdose, hemorrhagic complications may arise; therefore, neutralization with protamine sulfate may be needed, keeping in mind the possible occurrence of adverse reactions throughout this process. To prevent infection during administration, the patient's skin and the instruments used should be thoroughly disinfected, and intramuscular injections are best avoided. This medication should be used immediately after opening, and any remaining solution should be discarded.

Serious side effects

Urticaria, severe swelling (angioedema), chest tightness (sensation of pressure), difficulty breathing, shock, thrombocytopenia, heparin-induced thrombocytopenia (HIT), heparin-induced thrombocytopenia and thrombosis (HITT), acute adrenal insufficiency, bleeding (including fatal bleeding), adrenal hemorrhage, ovarian hemorrhage, retroperitoneal hemorrhage, thrombosis, cerebral hemorrhage, significant decrease in platelet count, vasospastic reactions, cyanosis, respiratory distress, bronchospasm,

Mild side effects

• Itching
• chills
• fever
• rhinitis
• bronchial asthma
• tearing
• conjunctivitis
• tachycardia
• pressure sensation
• hypotension

This medication should be stored in a sealed container to prevent exposure to air or moisture, and it is safe to keep it at room temperature between 1 and 30 degrees Celsius. Keeping it stored this way preserves the medication's effectiveness.

Appearance

A clear liquid that is colorless to pale yellow contained in a plastic vial

Package unit

20 milliliters/ampoule[* 50]