Huirions Injection 250 IU/mL (Heparin Sodium)

Adult dosage

Usage during extracorporeal circulation (hemodialysis): - Systemic heparinization: Administer 1,000 to 5,000 units before starting dialysis. - After initiation of dialysis: Continuously or intermittently add 500 to 1,500 units every hour. - Local heparinization: Continuous infusion of 1,500 to 2,500 units every hour. - Neutralize with protamine sulfate during in-body perfusion. The dosage is based on the whole blood coagulation time (Lee-White method) or whole blood activated partial thromboplastin time.

This drug is a very powerful medication and must only be used under the strict supervision of a physician. It should be administered with particular caution to patients with diseases that pose a high risk of bleeding, as bleeding can occur in nearly all parts of the body in patients receiving this medication. Deathly bleeding may occur; therefore, it must be used with extreme care. Additionally, serious bleeding such as adrenal hemorrhage, ovarian hemorrhage, and retroperitoneal bleeding may occur during the administration of this drug, requiring careful attention. Patients allergic to this medication or those with impaired blood coagulation functions, patients with existing bleeding conditions or those at high risk for bleeding, should not be administered this drug. Patients with severe liver or kidney dysfunction, those who have recently undergone central nervous system or eye surgery, or those who have received spinal anesthesia should also avoid using this medication. Moreover, patients who have experienced severe thrombocytopenia due to this medication or similar drugs should refrain from administration. This drug can cause various side effects, including thrombocytopenia, bleeding, liver dysfunction, allergic reactions, and skin anomalies; therefore, symptoms must be observed attentively during use. Especially, platelet counts should be verified regularly through blood tests, and if they decrease significantly, administration should be stopped immediately. This drug may interact with other medications, and concomitant use with acetylsalicylic acid, non-steroidal anti-inflammatory drugs, and anticoagulants may increase the risk of bleeding, so it is essential to consult a professional. Women who are pregnant or may become pregnant should exercise special caution when using this drug due to risks of uterine and placental bleeding. This medication does not excrete into breast milk and is not absorbed via the gastrointestinal tract, so it is generally not problematic when breastfeeding. In children or the elderly, the risk of bleeding may be higher, so management should be more cautious during use. In cases of overdose, bleeding may worsen, so if overdose is suspected, treatment with the antidote protamine sulfate should be administered immediately, while also being vigilant for side effects during this process. When administering this drug, patient skin and the instruments used must be thoroughly disinfected to prevent injection site infections, and intramuscular injection should be avoided due to the risk of hematoma. Any unused solution after opening should be discarded immediately.

Serious side effects

urticaria, thrombocytopenia, angioedema, shock, bleeding, adrenal hemorrhage, ovarian hemorrhage, retroperitoneal hemorrhage, arterial and venous thrombosis due to thrombocytopenia, heparin-induced thrombocytopenia (HIT), heparin-induced thrombocytopenia and thrombosis (HITT), chest tightness, difficulty breathing, bronchial asthma, severe allergic reactions, shortness of breath, severe skin adverse reactions, liver abnormalities (jaundice), severe edema or urinary abnormalities

Mild side effects

• itchiness
• chills
• fever
• rhinitis
• tearing
• conjunctivitis
• cyanosis
• tachycardia
• sense of pressure
• nausea

This drug should be stored in a sealed container to prevent exposure to air, and it is important to maintain a storage temperature between 1 degree to 30 degrees Celsius. Proper storage will preserve the effectiveness and safety of the medication.

Appearance

The injection is in a plastic container filled with a colorless to light yellow transparent liquid.

Package unit

Ampoule - 20 milliliters/ampoule [X 50], Ampoule - 10 milliliters/ampoule [X 50]