Sitagliptin Alpha 100 mg Tablet (Sitagliptin Hydrochloride Hydrate)

Adult dosage

The recommended dosage is 100 mg once daily, either as monotherapy or in combination therapy, with a maximum daily dose of 100 mg. It can be taken without regard to meals. For patients with renal impairment, dosage adjustments are necessary. - Mild renal impairment (glomerular filtration rate [GFR] 60-90 mL/min/1.73 m2): No dosage adjustment necessary. - Moderate renal impairment (GFR 45-60 mL/min/1.73 m2): Dosage adjustment required.

This medication may rarely cause serious allergic reactions; thus, if symptoms such as rash, difficulty breathing, or swelling of the face or neck occur within three months of administration, the medication should be stopped immediately and a doctor consulted. This medication has been reported to cause serious side effects, such as pancreatitis, which is inflammation of the pancreas; therefore, if symptoms like abdominal pain, vomiting, or loss of appetite occur during treatment, medical personnel should be informed immediately. Patients with type 1 diabetes, diabetic ketoacidosis, or those allergic to this medication or its components should not take it. Patients with reduced kidney function need adjustments in the dosage of this medication; therefore, it is important to have kidney function tests before and during treatment. Mild side effects such as upper respiratory infections, nasopharyngitis, headaches, diarrhea, nausea, constipation, muscle pain, limb pain, back pain, itching, thrombocytopenia, indigestion, dizziness, increased triglycerides in the blood, gastritis, weight loss, hypertension, hypernatremia, and erectile dysfunction may occur during the use of this medication, but most are temporary. When taken with other hypoglycemic agents, especially insulin or sulfonylureas, the risk of hypoglycemia may increase; therefore, careful monitoring of blood sugar levels is required. If severe joint pain or blistering skin symptoms occur, the doctor should be informed immediately, and medication may need to be discontinued if necessary. Pregnant or planning to become pregnant women, nursing women, and children under 18 years old should not use this medication as its safety has not been established. Elderly individuals should monitor kidney function and adjust the dosage for safe use as decreased kidney function is common in this population. In the event of an overdose, immediate medical attention is required, and this medication can be partially removed by hemodialysis. This medication has a low risk of interactions with other drugs; however, monitoring blood levels of digoxin is advisable when used concurrently.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, rash, Stevens-Johnson syndrome, exfoliative skin disease, acute pancreatitis, worsening kidney function (acute renal failure), severe and disabling joint pain, bullous pemphigoid, acute pancreatitis, pneumonia, diabetic complications, metabolic acidosis, cardiac arrest

Mild side effects

• Nasopharyngitis
• upper respiratory infection
• headache
• diarrhea
• nausea
• constipation
• muscle pain
• limb pain
• back pain
• itching

Store this medication in a tightly closed container to prevent exposure to air or moisture. It is also important to maintain a normal room temperature between 1 and 30 degrees Celsius when storing the medication.

Appearance

Light orange, round, bilayer film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP×3]