Samsita 50 mg (Sitagliptin Hydrochloride Hydrate)

Adult dose

The usual dose of this medication is 100 mg administered once daily, either as monotherapy or in combination therapy, with a maximum daily dose of 100 mg. Dose adjustments are necessary for patients with renal impairment. For mild to moderate renal impairment (glomerular filtration rate 30-45 mL/min/1.73 m2), the dose is 50 mg once daily. For severe renal impairment (glomerular filtration rate 15-30 mL/min/1.73 m2) or end-stage renal disease (glomerular filtration rate < 15 mL/min/1.73 m2), the recommended dose is 25 mg once daily.

This medication can very rarely cause serious allergic reactions; therefore, if symptoms such as rash, difficulty breathing, or swelling of the face or neck occur after taking the medication, discontinue use immediately and consult a doctor. It may also cause a serious inflammation of the pancreas called pancreatitis; thus, if abdominal pain, nausea, vomiting, or sudden weight loss occurs during use, inform medical personnel immediately. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and it should be avoided in those with allergies to the drug or its components. Patients with impaired kidney function may experience delayed excretion of this medication, necessitating dose adjustments or careful use as directed by a physician. During treatment with this medication, side effects such as cold-like symptoms, headache, indigestion, diarrhea, and nausea may occur, and hypoglycemic symptoms might also be experienced; hence, it is important to regularly monitor blood sugar levels. Particularly, when taken with insulin or sulfonylureas, the risk of hypoglycemia may be increased, warranting dosage adjustments of these medications. This medication can cause severe joint pain or skin blistering conditions; thus, any such symptoms should be reported to a physician immediately. Pregnant or nursing women are advised against taking this medication, and its safety and efficacy have not been established in children or adolescents under 18 years of age. Elderly patients should be evaluated for renal function before starting this medication and regularly assessed thereafter due to potential renal impairment. In case of overdose, standard emergency treatment should be initiated, and hemodialysis may be employed to remove the medication if necessary. This medication has minimal interactions with other diabetes treatments or certain medications but caution is required when taking specific drugs; consultation with a doctor or pharmacist is recommended.

Serious side effects

Hypersensitivity reactions (anaphylaxis, angioedema, urticaria, rash, cutaneous vasculitis, Stevens-Johnson syndrome, exfoliative skin diseases), acute pancreatitis (fatal/non-fatal hemorrhagic or necrotizing pancreatitis), acute renal failure (occasionally requiring dialysis), severe and disabling joint pain, bullous pemphigoid, pneumonia, diabetes complications, metabolic acidosis, falls, cardiac arrest, rhabdomyolysis

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• headache
• constipation
• vomiting
• muscle pain
• limb pain
• back pain
• pruritus
• thrombocytopenia

Store this medication in a tightly closed container to prevent air ingress, and keep it at room temperature between 1 to 30 degrees Celsius. This will help maintain the medication's effectiveness.

Appearance

Pale yellow pink round biconvex film-coated tablet

Package unit

30 tablets - 10 tablets/PTP [x3]