Janudau Tablet 100 mg (Sitagliptin Hydrochloride Monohydrate)

Adult dose

Administer 100 mg once daily for monotherapy or combination therapy, with a maximum daily dose of 100 mg. Can be taken regardless of meals. For patients with renal impairment, no dosage adjustment is necessary for mild to moderate renal impairment (glomerular filtration rate [eGFR] 45 to less than 90). For eGFR 30 to less than 45, administer 50 mg once daily. For eGFR 15 to less than 30,

This medication may cause allergic reactions, so if symptoms such as skin rash, hives, or difficulty breathing occur during use, it should be discontinued immediately and consult a physician. Moreover, acute pancreatitis, a serious pancreatic inflammation, may occur, so it is important to carefully observe for abdominal pain, vomiting, or severe nausea and to discontinue use if symptoms are suspected. It should not be administered to patients with type 1 diabetes or diabetic ketoacidosis, and use should be avoided if there is hypersensitivity to this medication or its components. For patients with impaired kidney function, the dosage must be adjusted as the drug may not be adequately excreted from the body, especially in patients with end-stage renal disease undergoing dialysis, where low-dose usage is recommended. When used in combination with other hypoglycemic agents, there may be an increased risk of hypoglycemia, so caution should be exercised for hypoglycemic symptoms when taking insulin or sulfonylureas, and adjustments to the dosages of other medications may be necessary. Severe arthralgia or blistering skin diseases may occur, and if such symptoms arise, inform a physician immediately and consider discontinuing the medication. Use of this medication is not recommended during pregnancy or breastfeeding, and safety and efficacy have not been established for children and adolescents under 18 years of age. Elderly individuals may have impaired kidney function, so it is advisable to evaluate kidney function before administration and to periodically check kidney status after administration. In case of overdose, general symptomatic treatment should be initiated, and blood dialysis may be considered to remove some of the drug if necessary. This medication has no issues with cardiovascular safety; however, some adverse reactions such as upper respiratory infections, headaches, rhinitis, diarrhea, and nausea have been reported, so caution is advised if symptoms occur. Finally, there are no significant interactions with other medications, but there may be a slight increase in blood levels when taken with digoxin, so monitoring is necessary.

Serious side effects

Hives, severe swelling (edema), anaphylaxis, angioedema, cutaneous vasculitis, Stevens-Johnson syndrome, exfoliative dermatitis, fatal/non-fatal hemorrhagic or necrotizing pancreatitis, acute pancreatitis, acute kidney failure, severe and disabling arthralgia, blistering dermatitis, pneumonia, diabetic complications, metabolic acidosis, cardiac arrest

Mild side effects

• Rhinitis
• upper respiratory infection
• headache
• diarrhea
• nausea
• constipation
• myalgia
• limb pain
• back pain
• pruritus

This medication should be stored in a tightly closed container to prevent air from entering, and it is recommended to store it at room temperature between 1 to 30 degrees Celsius. This will help maintain the effectiveness of the medication.

Appearance

Light orange, round, biconvex film-coated tablet

Package unit

30 tablets/box (10 tablets/PTP X 3)