Exiglu 10 mg (Dapagliflozin)

Adult dose

Take 10 mg orally once daily as monotherapy or additional therapy. In initial combination therapy, doses of 5 mg or 10 mg can be taken once daily. The recommended dosage for chronic heart failure and chronic kidney disease patients is also 10 mg once daily, regardless of meals, taken at any time of the day, and the tablet should be swallowed whole.

Child dose

Not recommended as safety and efficacy have not been established in pediatric patients under 18 years.

This drug should not be used in certain patients. It is contraindicated for patients with allergies to the ingredients or additives, type 1 diabetes patients, patients with diabetic ketoacidosis, and those with genetic disorders affecting lactose breakdown. Moreover, it should not be used in patients undergoing dialysis. Precautions should be taken when administering to patients with decreased fluid volume or impaired kidney function. This drug may lower blood pressure or affect kidney function, so caution is particularly required for older patients, those with poor kidney function, and patients taking diuretics. Blood pressure and kidney function should be periodically monitored during treatment, and the effect on blood sugar control may vary depending on kidney function. Adverse effects such as genital infections, urinary tract infections, hypoglycemia, decreased fluid volume, diabetic ketoacidosis may occur with this medication. Notably, genital infections are more common in women, and immediate treatment is required if symptoms of infection appear. If symptoms of ketoacidosis occur despite low blood sugar levels, immediate medical attention is necessary, as this drug poses a risk for ketoacidosis. This drug may affect kidney function, so any abnormal symptoms related to kidney should be discussed with a doctor. Severe skin and tissue infections such as perineal necrosis have been rarely reported, so immediate medical attention is needed if there is pain, swelling, or redness around the genital area. Women who are pregnant or planning to become pregnant should not use this medication; similarly, it should be avoided while breastfeeding. The safety and efficacy of this drug in children have not been established, thus it should not be used in this population. In the event of an overdose, as there is no specific antidote, appropriate treatment based on symptoms is necessary. Patients should be cautious of the risk of hypoglycemia when driving or operating machinery while taking this medication. Caution is warranted when using this drug concurrently with other diuretics, insulin, or sulfonylureas, as the risk of hypoglycemia or dehydration may increase, requiring dose adjustments according to physician instructions. This drug should be stored in its original container and kept out of reach of children.

Serious side effects

Rash, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or breathing difficulties, asthma attacks, respiratory irregularities accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme fatigue, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

Vulvovaginitis, balanitis, related genital infections, urinary tract infections, hypoglycemia, dizziness, constipation, dry mouth, back pain, painful urination, polyuria, nocturia, increased hematocrit, decreased creatinine clearance during the initial treatment, dyslipidemia, increased blood urea nitrogen, weight loss, edema, fever, foreign body sensation, facial swelling, facial pain, warmth, flu-like symptoms, itching, rash, sweating, joint pain, musculoskeletal pain, limb pain, muscle

This medication must be stored in a tightly sealed container to prevent exposure to air or moisture. It is important to maintain storage temperatures between 1 to 30 degrees Celsius to ensure the medication retains its effectiveness.

Appearance

Yellow oval film-coated tablet

Package unit

10 tablets/bottle, 30 tablets/bottle