Donepezil 10 mg (Donepezil Hydrochloride Hydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before sleep. After 15 days, normal levels will be reached, and maintain the 5 mg dose for 4-6 weeks. After evaluating clinical response, the dose may be increased to 10 mg. Caution should be exercised for gastrointestinal adverse reactions during dose escalation. Underweight female patients over 85 years of age should not exceed 5 mg per day and require careful monitoring.

Child dose

There is no experience regarding the use of this medication in children.

This medication contains Donepezil Hydrochloride Hydrate as its active ingredient and is primarily used for alleviating the symptoms of Alzheimer's type dementia. This medication should not be administered to certain patients. For example, patients who are allergic to this drug or its components, women who are pregnant or may become pregnant, and women who are breastfeeding should not take it. In addition, patients with genetic lactose intolerance, lactose enzyme deficiency, or glucose-galactose malabsorption should also avoid taking this medication. Patients with heart diseases should exercise caution when using this medication as it may slow heart rate or induce arrhythmias. Patients currently taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers need to use this medication cautiously due to the possibility of gastrointestinal bleeding or ulcer exacerbation. Patients with a history of asthma or chronic obstructive pulmonary disease may also experience worsening symptoms while taking this medication, thus requiring caution. Patients with extrapyramidal disorders such as Parkinson's disease should also be administered this medication carefully as it may exacerbate symptoms. This medication contains the pigment Yellow No. 5, and caution should be exercised if there is an allergy to this component. Various adverse reactions may occur during treatment. Cardiac-related issues, such as bradycardia, heart block, and myocardial infarction have been reported, while gastrointestinal effects may include ulcers or bleeding, nausea, vomiting, and diarrhea. Additionally, serious side effects such as liver dysfunction, cerebrovascular issues, seizures, muscle abnormalities, respiratory distress, acute pancreatitis, acute renal failure, and sudden death may occur; if symptoms appear, medical consultation should be sought immediately. Consultation with a medical professional is recommended if psychiatric issues such as hallucinations, anxiety, insomnia, confusion, or depression arise, while neurological issues like dizziness, seizures, and tremors have also been reported. This medication is approved only for patients with Alzheimer's type dementia and is not to be used for other types of dementia or memory declines. Treatment should be carried out under the supervision of an experienced physician, with regular evaluations of treatment efficacy and discontinuation when necessary. Patients with cardiovascular diseases or a history of prolonged QT interval should have periodic ECG assessments to monitor their condition while taking this medication. This medication is metabolized by the enzymes CYP3A4 and CYP2D6 in the liver, so caution is needed when taken concurrently with drugs that inhibit or induce these enzymes as it may alter the effectiveness. Women who are pregnant or breastfeeding should avoid taking this medication and should consult with a specialist prior to use, even if absolutely necessary. Safety for children has not been established, so use is not recommended. In case of overdose, severe nausea, vomiting, bradycardia, hypotension, convulsions, and respiratory suppression may occur, requiring immediate emergency treatment. This medication should be kept out of reach of children and transferring it to other containers may not be good for maintaining quality.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with fever, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, shortness of breath or difficulty breathing, asthma attack, cough with fever indicating respiratory issues, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, lightning headache, seizures, confusion of consciousness, visual impairments, paralysis, urinary

Mild side effects

• Decreased appetite
• nausea
• vomiting
• diarrhea
• headache
• fatigue
• dizziness
• insomnia
• hallucinations
• excitement

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. It is also advisable to avoid extremely hot or cold places and store it at room temperature between 1°C and 30°C.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle