Unirin Tablets 0.1 mg (Desmopressin Acetate)

Adult dose

Treatment of nocturia associated with nocturnal polyuria (adults only): Administer desmopressin acetate 0.1mg orally at bedtime. If the effect is insufficient after 1 week, increase the dose to 0.2mg; if the effect remains insufficient, the dose may be increased at 1-week intervals up to 0.4mg. If there is no clinical effect within 4 weeks after dose determination, discontinue treatment. Initiation of treatment with this medicine is not recommended in patients aged 65 years or older. If treatment is necessary in an older patient, closely monitor serum sodium levels, etc. (Refer to 5. General Precautions under Precautions for Use)

Child dose

Primary nocturnal enuresis (5 years of age and older): Administer desmopressin acetate 0.2mg orally at bedtime. If the effect is insufficient, the dose may be increased to 0.4mg. Whether to continue treatment should be determined after 3 months of administration, following a treatment-free period of at least 1 week.

This medication acts by regulating the body’s fluid balance and may cause side effects such as hyponatremia or water intoxication; therefore, it is especially important for the elderly or patients with certain diseases to limit fluid intake. This medication should not be administered to patients with hypersensitivity, severely impaired cardiac function, those taking diuretics, patients with renal failure, or those with specific diseases. Pregnant women or those who may become pregnant, patients with hypertension or chronic kidney disease, as well as children and elderly patients should exercise increased caution when using this medication, and it should be administered under the physician's discretion if necessary. During the course of treatment with this medication, strict limitations on fluid intake should be maintained; excessive fluid intake can lead to symptoms such as headaches, nausea, weight gain, and in severe cases, seizures. Side effects may include hyponatremia, headaches, dizziness, and allergic reactions, and there is a higher risk of serious symptoms such as coma or seizures in the elderly. This medication may interact with other drugs, so caution is needed when taken with tricyclic antidepressants, diuretics, corticosteroids, and non-steroidal anti-inflammatory drugs. Pregnant women should use this medication only when absolutely necessary as it may cause uterine contractions, and breastfeeding women are advised to discontinue breastfeeding while using this medication. In cases of overdose, symptoms such as fluid retention and hyponatremia, leading to headaches, nausea, seizures, and loss of consciousness may occur, necessitating immediate medical attention, and treatment such as diuretic administration or fluid restriction may be required.

• coma
• convulsions
• weight gain
• severe water intoxication
• hyponatremia
• allergic reaction
• emotional disturbance
• headache
• abdominal pain
• nausea

This medication should be stored in a sealed container to protect it from air and moisture. A suitable storage temperature is room temperature between 1°C and 30°C. This will help maintain the medication’s effectiveness for a longer duration.

Appearance

White oval tablet

Package unit

30 tablets/bottle