Clarithromycin 250mg Tablet

Adult dosage

○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal impairment and creatinine clearance of 30mL/min or less, the dose should be halved: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days in these patients. ○ Mycobacterial infections: Administer 500mg (potency) of this drug per dose twice daily. In this case, it should be administered concomitantly with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this drug 3 times daily for 14 days together with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (Days 1～14), and omeprazole 40mg once daily for 28 days (Days 1～28).

Children's dosage

○ Children 12 years of age and older: Same as adults. ○ Children under 12 years of age: Use clarithromycin oral suspension.

This medication should not be used in patients with known allergies or hypersensitivity to certain ingredients. Patients allergic to macrolide antibiotics or with a history of side effects should also avoid its use. Concurrent use with certain heart-related medications may cause cardiac abnormalities; therefore, patients on such medications should not use this drug. It is also advisable not to administer this drug to those with severe cardiac, liver, or kidney impairment, and to pregnant or breastfeeding women. Caution is required in patients with central nervous system infections or those taking certain other medications. Patients with liver or kidney dysfunction, those with heart disease, and the elderly must use this drug more carefully. Caution is warranted if combined with other antibiotics or in the event of a drug allergy. Rarely, this medication can cause severe allergic reactions or shock. If symptoms appear, immediately discontinue use and inform medical staff. Gastrointestinal symptoms may include nausea, vomiting, or diarrhea; if severe abdominal pain or persistent diarrhea occurs, discontinue use immediately. Various side effects such as respiratory issues, skin rash, liver dysfunction, kidney impairment, and blood anomalies have been reported, so consult medical staff if symptoms occur. Long-term or high-dose use of this medication may lead to tinnitus or hearing loss; thus, caution is necessary. It is important to take this medication only for the required duration to prevent antibiotic resistance. Since this drug interacts with many other medications, inform medical staff if you are taking any other drugs. It is preferable to avoid this drug during pregnancy or breastfeeding, and if unavoidable, breastfeeding should be discontinued. Special caution is needed for children and the elderly, with potential dosage adjustments required. In case of overdose, gastrointestinal symptoms may occur, necessitating immediate medical attention. This medication should be stored in a cool, dark place and not refrigerated.

Shock, anaphylactic symptoms, shortness of breath, convulsions, flushing, rash, itching, hives, skin erythema, angioedema, joint swelling, drug rash, abdominal bloating, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal ulceration, upper abdominal pain, thirst, tooth discoloration, pancreatitis, increased amylase, taste disturbance, anorexia, constipation, discoloration of stools, membranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, tremor, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, lethargy, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, hearing impairment, cardiac arrest, atrial fibrillation, QT prolongation on ECG, premature contractions, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, abdominal distension, acute pancreatitis, tongue discoloration, vesicular dermatitis, hyperhidrosis, papular rash, acne, Henoch-Schonlein purpura, acute generalized exanthematous pustulosis, muscle cramps, musculoskeletal stiffness, myopathy, elevated blood urea, nephritis, injection site phlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color, changes in mental status, obsessional behavior, hypokalemia, hypoxemia

This medication should be stored at room temperature between 1°C and 30°C. It should be kept in a sealed container to avoid exposure to direct sunlight and air.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle