Retamine 250 mg (Clarithromycin)

Adult dosage

○ Adults : The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The treatment period is usually 7～14 days. In patients with renal failure and creatinine clearance of 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer this medicine to these patients for more than 14 days. ○ Mycobacterial infections : Administer 500mg (potency) of this medicine twice daily. In this case, it should be administered concomitantly with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers : Administer 500mg (potency) of this medicine three times daily for 14 days with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1–14), and omeprazole 40mg once daily for 28 days (days 1–28).

Children's dosage

Children aged 12 years or older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This drug should not be administered to certain patients. Patients who are allergic to any of the ingredients or have had hypersensitivity reactions to specific antibiotics should not use this product. Additionally, patients with cardiac rhythm disorders, severe liver dysfunction, or severe kidney dysfunction may be at risk if they take this medication. It is advisable for pregnant or breastfeeding women to avoid this drug. Because there are other drugs that may be dangerous when taken together, patients should consult their doctor or pharmacist if they are currently taking any other medications. This drug should be used cautiously in patients with weak liver or kidney function, those with heart disease, the elderly, and patients taking other antibiotics. Patients with a history of allergies or sensitivity to dyes in this medication must also take precautions. This medication can sometimes cause serious allergic reactions, skin rashes, gastrointestinal disturbances, liver dysfunction, kidney issues, central nervous system disturbances, hearing loss, among various side effects. If any of these symptoms occur, discontinue use immediately and consult a healthcare professional. To prevent antibiotic resistance, it should only be taken for the required duration, and if symptoms like diarrhea or abdominal pain persist, medical advice should be sought immediately. Furthermore, because this drug has many interactions with other medications, it is essential to report any concurrent use of other drugs, and regular blood tests or electrocardiograms may be necessary. It is safe for pregnant or nursing women to refrain from using this drug, and in children, usage may be restricted according to age. The elderly may require dosage adjustments as drug concentrations can increase due to declining physical function. In case of overdose, gastrointestinal disturbances or central nervous system symptoms may occur. If suspected, seek medical attention promptly.

shock, anaphylactic symptoms, dyspnea, seizures, flushing, rashes, itching, urticaria, skin flushing, angioedema, joint swelling, drug rash, abdominal bloating, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disorders, anorexia, constipation, discoloration of stools, membranous colitis, hemorrhagic colitis, fever, cough, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis exacerbation, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, seizures, tremors, sensation of numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, elevated LDH, raised ALP, increased total bilirubin, elevated serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory disorder, hypoglycemia, tinnitus, auditory impairment, petechial rash, acute generalized exanthematous pustulosis (AGEP), muscle cramps, musculoskeletal stiffness, myopathy, increased blood urea, injection site phlebitis, injection site pain, injection site inflammation, fever, myasthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, increased serum alkaline phosphatase, elevated blood lactate dehydrogenase, increased INR, prolonged prothrombin time, urine discoloration, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, vesicular dermatitis, hyperhidrosis, papular rash, acne, Henoch-Schonlein purpura

Store this medication in a tightly closed container to protect it from air and moisture. It is best to maintain a storage temperature between 1 to 30 degrees Celsius.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle