Famciclovir 250 mg Tablets

Adult dose

1. Treatment of herpes zoster infections Adults: Administer famciclovir 250 mg per dose orally 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of initial genital herpes infections Adults: Administer 250 mg of this medicine per dose orally 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes infections Adults: Administer 125 mg of this medicine per dose orally twice daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer 250 mg of this medicine per dose orally twice daily. Periodically discontinue treatment every 6～12 months to assess changes in the natural course of the disease. 5. Patients with renal impairment: Since creatinine clearance of this medicine is reduced in patients with renal impairment, dose adjustment should be undertaken with caution. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and initial genital herpes infections: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose twice daily 10～29 250 mg per dose once daily 2) Treatment of acute recurrent genital herpes infections: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 125 mg per dose twice daily 10～29 125 mg per dose once daily 3) Suppression of recurrent genital herpes infections: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose twice daily 10～29 125 mg per dose twice daily 4) If only serum creatinine is known, creatinine clearance can be calculated using the following formulas. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients on hemodialysis, it is preferable to administer the medicine every 48 hours, taking the dialysis interval into account. Four hours of hemodialysis reduces the plasma concentration of this medicine by approximately 75%; therefore, administer this medicine immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dose adjustment is necessary in patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, no clear recommended dose has been established.

This medication should not be used by those who are allergic to specific components or who have previously experienced hypersensitivity reactions. Additionally, this medication contains lactose, so patients with a genetic disorder that affects lactose digestion should not use it. Patients with compromised kidney function should use this medication with caution, as dosage adjustment may be necessary. Taking this medication may result in symptoms such as headache or nausea, but most occurrences are mild to moderate. Rarely, a decrease in blood cell count, confusion, hallucinations, and other symptoms may occur, so consult a physician if any unusual symptoms arise. This medication does not completely cure genital herpes, so it is important to avoid sexual contact when symptoms are present and to maintain safe sex practices. If dizziness or drowsiness occur during treatment, driving or operating machinery should be avoided. Patients with slightly impaired liver function do not require special dosage adjustment, but those with severe liver disease may experience reduced efficacy. This medication has a low potential for interactions with other medications, but caution may be required when taken with specific drugs. Pregnant or breastfeeding women should use this medication cautiously, as its safety has not been fully established. Children under 18 years old should not use this medication, as its safety and efficacy have not been established. Generally, the elderly do not require dosage adjustments, but elderly patients with reduced kidney function may need dosage adjustments. In the case of overdose, seek medical attention immediately, and blood dialysis can reduce the drug concentration. This medication should be stored in a cool, dry place below 30 degrees Celsius, kept out of reach of children, and should not be transferred to another container.

• headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This medication must be stored in a tightly sealed container to protect it from air and moisture. It is recommended to store it in a cool, dry place below 30 degrees Celsius.

Appearance

White round film-coated tablets

Package unit

Domestic use - 21 tablets/PTP [(7 tablets/PTP x 3)]