Atracen Semis Tablet

Adult dose

Children 12 years and older, and adults: The dosage should be adjusted according to the level of pain and the treatment response. It is recommended to administer an initial dose of 4 tablets, followed by a minimum interval of 6 hours for subsequent doses, but do not exceed 16 tablets in one day. Administer the lowest effective dose for the shortest duration possible. Avoid prolonged use beyond what is necessary, and if long-term use is required due to the nature and severity of the disease, regular monitoring must be conducted to determine the continued administration of this drug. Elderly: Administer the usual adult dosage. However, for elderly patients over 75 years, when tramadol is taken orally, the elimination half-life of tramadol increases by 17%, so this drug should be taken at least a minimum of 6 hours apart. Renal impairment: For patients with moderate renal impairment (creatinine clearance 10-30 ml/min), extend the dosing interval to 12 hours. For patients with severe renal impairment (creatinine clearance less than 10 ml/min), administration is not recommended. Tramadol is removed very slowly during hemodialysis and filtration, so it is not necessary to re-administer this drug after dialysis for the maintenance of analgesic effect. Hepatic impairment: Carefully consider extending the dosing interval for patients with moderate hepatic impairment. This drug should not be administered to patients with severe hepatic impairment.

Child dose

Children 12 years and older, and adults: The dosage should be adjusted according to the level of pain and the treatment response. It is recommended to administer an initial dose of 4 tablets, followed by a minimum interval of 6 hours for subsequent doses, but do not exceed 16 tablets in one day.

This medication may burden the liver, so individuals who consume large amounts of alcohol daily should consult with a doctor or pharmacist before taking this drug. There is a risk of liver damage. This drug can rarely cause serious skin reactions; if a rash or hypersensitivity occurs, discontinue use immediately and seek medical attention. The tramadol component of this medication may induce seizures; therefore, patients with a history of seizures or those at high risk of seizures should be cautious. The risk of seizures increases especially when taken with certain antidepressants or opioids. Serious allergic reactions can occur occasionally; seek emergency treatment if symptoms like difficulty breathing or hives appear. In patients with acute bronchial asthma, this medication may severely suppress breathing, so it must be administered in a medically equipped environment. Taking this drug with alcohol or central nervous system depressants may lead to severe drowsiness, respiratory depression, or coma, so co-administration should be avoided. In patients with brain injuries or elevated intracranial pressure, this drug may worsen their condition, requiring caution. This medication may cause both psychological and physical dependence, so long-term use should strictly follow a doctor's instructions. As the acetaminophen component can harm the liver, patients with liver diseases or compromised liver function must consult with a doctor before use. Patients who metabolize tramadol rapidly due to genetic factors may be at a higher risk of respiratory depression, requiring dose adjustment and careful monitoring. Children under 12 years old and adolescents under 18 years who have undergone tonsillectomy or adenoidectomy should not use this drug, and adolescents aged 12 to 18 should also avoid it if there are risk factors. This medication may cause sleep apnea or hypoxia, and if such symptoms appear or worsen, it is necessary to reduce or discontinue the dosage. Elderly patients or those at risk for hyponatremia should be closely observed for potential development of hyponatremia. This drug may interact with certain medications, so patients must inform their doctor or pharmacist about any other medications they are taking. Women who are pregnant or may become pregnant, as well as nursing mothers, should consult with healthcare professionals before taking this drug, as it could have serious effects on the baby during breastfeeding. Drowsiness or dizziness may occur during use, so caution is advised when driving or operating machinery. In case of overdose, serious respiratory depression, seizures, liver damage, etc., may occur, so the recommended dosage must be strictly adhered to, and in case of overdose, immediate emergency treatment is required. This medication should be stored in a safe place out of the reach of children, and care should be taken to prevent misuse or abuse.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/eye mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by cough + fever, yellowing of skin or eyes (jaundice), profound drowsiness, sudden and severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, urination issues

Mild side effects

• Decreased appetite
• insomnia
• depression
• dizziness
• headache
• drowsiness
• nausea
• vomiting
• constipation
• dry mouth

Store this medication in a tightly sealed container to prevent air or moisture exposure. It is also recommended to keep it away from direct sunlight and at room temperature below 25 degrees Celsius.

Appearance

Light yellow oblong film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle