Nicotin ES Tablet 1 mg (Varenicline Salicylate)

Adult dose

After dose titration over 1 week, administer 1 mg twice daily. Days 1–3: 0.5 mg once daily Days 4–7: 0.5 mg twice daily Day 8 until end of treatment: 1 mg twice daily In patients who cannot tolerate the adverse reactions of this medicine, the dose may be reduced temporarily or permanently. The treatment period with this medicine is 12 weeks. For patients who successfully quit smoking with the first 12 weeks of treatment, an additional 12 weeks of treatment with this medicine is recommended to increase the likelihood of long-term abstinence. Continue treatment with this medicine for an additional 12 weeks, for a total treatment period of 24 weeks. No dosage adjustment is necessary in patients with mild (estimated creatinine clearance > 50 mL/min and ≤ 80 mL/min) to moderate (estimated creatinine clearance ≥ 30 mL/min and ≤ 50 mL/min) renal impairment. In patients with severe renal impairment (estimated creatinine clearance < 30 mL/min), the recommended starting dose of varenicline is 0.5 mg once daily. If necessary, the dose may be increased to a maximum of 0.5 mg twice daily. In patients with end-stage renal disease receiving hemodialysis, if well tolerated, the maximum dose is 0.5 mg once daily. No dosage adjustment is necessary in patients with hepatic impairment.

Child dose

Under 18 years: The safety and efficacy of this medicine have not been established in children; therefore, use in patients under 18 years of age is not recommended.

This medication is intended to assist with smoking cessation, and serious neuropsychiatric symptoms may occur during treatment, so caution is needed. If there is a history of psychiatric disorders, it is essential to inform your doctor before taking this medication, and if symptoms such as depression, anxiety, or suicidal thoughts occur during treatment, discontinue use immediately and consult a doctor. This medication should not be used in patients with hypersensitivity, and caution should be exercised in pregnant or breastfeeding women. The most common side effect is nausea, which is generally mild, but may persist in some patients. Additionally, quitting smoking itself can trigger various symptoms such as depression, insomnia, and anxiety, so care should be taken if these symptoms occur during treatment. This medication may increase the risk of seizures, so patients with a history of seizures or risk factors for seizures should consult a doctor before use. Caution is advised for activities requiring attention, such as driving or operating machinery, after taking this medication. Alcohol consumption may exacerbate side effects, so it is advised to avoid or minimize alcohol intake during treatment. This medication is excreted through the kidneys, so dosage adjustments may be necessary for patients with reduced kidney function, especially for the elderly. There is no specific antidote for overdose, so appropriate treatment should be received based on symptoms, and keep out of reach of children.

• Suicidal thoughts
• suicidal behavior
• suicide
• changes in behavior or thoughts
• depression
• mania
• psychosis
• aggressive behavior
• hallucinations
• paranoia

Store this medication in a tightly sealed container to protect from air and moisture, at a temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication for a long time.

Appearance

Light blue, convex-shaped, film-coated tablets

Package unit

28 tablets (14 tablets/PTP X 2)