Lepatidine Tablet 10 mg

Adult dosage

1. Short-term treatment of gastric ulcers: The usual dose is lafutidine 10mg orally twice daily, in the morning and at bedtime. In clinical trials in which treatment was given for up to 8 weeks, most ulcers healed within 8 weeks; however, healing time may occasionally vary among patients. 2. Short-term treatment of duodenal ulcers: The usual dose is lafutidine 10mg orally twice daily, in the morning and at bedtime. In clinical trials in which treatment was given for up to 6 weeks, most ulcers healed within 6 weeks; however, healing time may occasionally vary among patients. 3. Improvement of gastric mucosal lesions associated with acute gastritis and chronic gastritis: The usual dose is lafutidine 10mg orally once daily at bedtime. In clinical trials in which treatment was given for up to 2 weeks, most lesions healed within 2 weeks; however, healing time may occasionally vary among patients. 4. Antibiotic combination therapy in patients with peptic ulcers infected with Helicobacter pylori: Administer lafutidine 20mg, clarithromycin 500mg, and amoxicillin 1000mg twice daily for 7 or 14 days. 5. Premedication for anesthesia: The usual dose is lafutidine 10mg per dose, administered orally twice (at bedtime on the day before surgery and 2 hours before anesthesia on the day of surgery). 6. Treatment of reflux esophagitis: Administer lafutidine 10mg per dose orally twice daily.

This medication should not be used in patients with hypersensitivity to its components. Since it contains lactose, patients with genetic problems such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption should not be administered this medication. Patients with a history of hypersensitivity or allergies to soybean oil, soybeans, and peanuts should also avoid using this medication. Patients with a history of drug hypersensitivity, impaired liver or kidney function, dialysis patients, the elderly, and those who must be cautious with lipid emulsions should use this medication carefully. This medication can cause severe allergic reactions such as anaphylaxis; if symptoms such as paleness, drop in blood pressure, and difficulty breathing occur, stop use immediately and seek appropriate treatment. Liver function impairment or jaundice may occur, so frequent liver function tests are necessary and the medication should be stopped if abnormalities are detected. Agranulocytosis or thrombocytopenia may develop, so if symptoms like sore throat, general malaise, or fever occur, stop use immediately. Rarely, serious side effects, such as rash, convulsions, and cardiac dysfunction, have been reported; consult a physician immediately if abnormal symptoms appear. Gastrointestinal side effects may include constipation, diarrhea, nausea, vomiting, abdominal distension, and loss of appetite. Central nervous system side effects have been reported, including headache, insomnia, drowsiness, confusion, hallucinations, altered consciousness, and dizziness. Cardiovascular symptoms may include cold extremities, heat sensation, and facial flushing. Blood tests may show increased or decreased white blood cell counts, decreased red blood cell count, and elevated liver enzyme levels. Renal function abnormalities may also occur, so it is recommended to conduct kidney function tests. Long-term use or high doses of this medication may obscure symptoms of malignant tumors; therefore, if symptoms such as weight loss, recurrent vomiting, or hematemesis occur, testing is essential. If gastric tumors are suspected, endoscopy or X-ray examination should be performed at an early stage, and if confirmed as malignant gastric cancer, administration should be discontinued immediately. During treatment, patients' conditions should be continuously monitored, and blood, liver, and kidney functions should be regularly checked. Patients at risk of lipid overload should have their plasma lipid levels checked and dosage adjusted if abnormalities are found, and if other lipid formulations are used, the lipid content should be considered in the adjustment. Elderly patients have reduced physical function; therefore, caution should be exercised in adjusting the dosage and administration interval, and their condition should be monitored. Dialysis patients may experience elevated blood drug concentrations; thus, careful administration starting at a low dose is recommended. Pregnant women should only use this medication if the benefits outweigh the risks based on medical judgment, and breastfeeding women should preferably avoid this medication as it may be secreted in breast milk. Safety in pediatric patients has not been established, so it is advisable not to use this medication in children. This medication should be kept out of reach of children, and storing it outside the original container may cause medication misuse or degradation in quality.

• Shock
• symptoms of anaphylaxis
• facial pallor
• hypotension
• generalized rash
• dyspnea
• liver dysfunction
• jaundice
• agranulocytosis
• pharyngitis

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius. Proper storage will help preserve the drug's effectiveness for a longer period.

Appearance

White, round film-coated tablet

Package unit

Bottle packaging - 30 tablets/bottle, Bottle packaging - 300 tablets/bottle