Nicochamps 1mg (Varenicline Tartrate)

Adult dose

Administer 1 mg 2 times daily. Days 1 – 3: 0.5 mg once daily Days 4 – 7: 0.5 mg 2 times daily Day 8 – end of treatment: 1 mg 2 times daily For patients who cannot tolerate the adverse reactions of this medicine, the dose may be reduced temporarily or permanently. The treatment period for this medicine is 12 weeks. For patients who successfully quit smoking with the first 12 weeks of treatment, it is recommended that this medicine be administered for an additional 12 weeks. Within the first 4 weeks after starting this medicine, patients should reduce their smoking by 50% compared with before starting treatment, and reduce it by a further 50% within the following 4 weeks. Smoking should continue to be reduced so that complete smoking cessation is achieved by week 12. Administer this medicine for an additional 12 weeks for a total treatment period of 24 weeks. No dose adjustment is required in patients with mild (estimated creatinine clearance > 50 ml/min and ≤ 80 ml/min) to moderate (estimated creatinine clearance ≥ 30 ml/min and ≤ 50 ml/min) renal impairment. In patients with severe renal impairment (estimated creatinine clearance < 30 ml/min), the recommended starting dose of varenicline is 0.5 mg once daily. If needed, the maximum dose is 0.5 mg 2 times daily. In patients with end-stage renal disease receiving hemodialysis, a maximum dose of 0.5 mg once daily may be administered if well tolerated. No dose adjustment is required in patients with hepatic impairment. In elderly patients, renal function is more likely to be reduced, so care should be taken when selecting the dose; monitoring renal function may be useful.

Child dose

Use is not recommended in patients under 18 years of age.

This medication is used to assist with smoking cessation. Serious psychiatric symptoms such as depression, anxiety, aggression, hallucinations, and suicidal thoughts may occur during treatment, so caution is required. If any of these symptoms or unusual behaviors appear, discontinue use immediately and consult a physician. This medication should not be used in patients with hypersensitivity, and caution is advised for women who are pregnant or breastfeeding. During the initial period of use, side effects such as nausea, headache, insomnia, and unusual dreams may commonly occur. Nausea is particularly the most common side effect, which generally appears mild to moderate but may persist for several months in some patients. Seizures may occur while taking this medication; therefore, patients with a history of seizures or at risk for seizures should consult a physician before use. When engaging in hazardous activities such as driving or operating machinery, caution is required due to possible drowsiness or decreased concentration. This medication may cause unusual and aggressive behavior when taken with alcohol; hence, it is advisable to avoid or minimize alcohol consumption during treatment. Patients with cardiovascular disease should carefully consider the risks and benefits of using this medication, and should inform a doctor immediately if any new or worsening cardiovascular symptoms arise. This medication is excreted through the kidneys; therefore, dose adjustment may be necessary for patients with impaired kidney function or the elderly, and it is important to monitor kidney function regularly. Its safety and efficacy have not been established in children, so it is not recommended for individuals under 18 years of age. In cases of overdose, there is no specific antidote, and standard treatment should be administered as necessary. This medication should be stored in its original container and kept out of the reach of children.

• Suicidal ideation
• suicidal behavior
• suicide
• changes in behavior or thoughts
• depression
• mania
• mood changes
• psychosis
• aggressive behavior
• hallucinations

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. Additionally, avoid storing it in excessively hot or cold places, ideally keeping it at a normal room temperature between 1 to 30 degrees Celsius.

Appearance

Light blue, biconvex, rectangular film-coated tablet

Package unit

28 tablets (14 tablets/BlisterX2)