Icadine Capsule 100 Milligrams (Itraconazole)

Adult dosage

To increase absorption, this medicine should preferably be taken immediately after a meal. The capsules must be swallowed whole. 1. Short-term treatment This medicine continues to exert a therapeutic effect in the skin tissue even after treatment is discontinued. Therefore, the final clinical and mycological response should preferably be assessed 2～4 weeks after completion of the prescribed treatment. 1) Candidal vaginitis: Administer itraconazole 200 mg twice daily (morning and evening) for 1 day, or 200 mg once daily for 3 days. 2) Pityriasis versicolor: Administer 200 mg once daily for 7 days. 3) Tinea corporis, tinea cruris: Administer 100 mg once daily for 15 days. 4) Tinea manuum (interdigital), tinea pedis (interdigital): Administer 100 mg once daily for 15 days. 5) Tinea manuum (palmar), tinea pedis (plantar): Administer 100 mg once daily for 30 days or 200 mg twice daily for 7 days. 6) Oral candidiasis: Administer 100 mg once daily for 15 days. 7) Fungal keratitis: Administer 200 mg once daily for 21 days. 2. Onychomycosis 1) Pulse therapy Administer 200 mg twice daily for 1 week, followed by 3 weeks without treatment; this constitutes 1 cycle. Administer up to 2 cycles for infection of the fingernails only, and up to 3 cycles for infection of the toenails. Affected area of onychomycosis Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Toenails (with or without concomitant fingernail infection) Treatment No treatment Treatment No treatment Treatment Fingernails Treatment No treatment Treatment 2) Continuous therapy Administer 200 mg once daily for 3 months. After treatment ends, the therapeutic effect continues for 3 months for fingernails and 6 months for toenails. 3. Systemic fungal infections In patients with impaired immune function, such as those with neutropenia, AIDS, or organ transplant recipients, the oral bioavailability of this medicine may be reduced; therefore, double the dose if necessary. Aspergillosis: 200mg once daily, 2~5 months. For invasive or disseminated disease, increase the dose to 200mg twice daily Candidiasis: 100~200mg once daily, 3 weeks~7 months Cryptococcal meningitis: 200mg twice daily, 2 months~1 year Maintenance therapy (for AIDS patients only): 200mg once daily2 Paracoccidioidomycosis: 100mg once daily, 6 months. There are no data on the efficacy of this dosage regimen for the treatment of paracoccidioidomycosis in ADIS patients. 1 The duration of treatment should be adjusted according to clinical response. 2 The duration of treatment should depend on immune recovery.

This medication should not be used in patients with poor cardiac function, especially those with congestive heart failure, as it can be life-threatening. Patients allergic to this medication or those with decreased cardiac function should avoid its use. Serious side effects may occur if taken with certain other medications, so it is essential to consult a doctor or pharmacist. Women who are pregnant or may become pregnant, as well as nursing mothers, should not take this medication. Patients with poor liver or kidney function should use this medication with caution and undergo regular liver function tests. This medication can rarely cause serious liver damage, allergic reactions, neurological problems, and hearing loss, so any unusual symptoms should be reported to a healthcare professional immediately. Symptoms such as dizziness, visual disturbances, and drowsiness may occur during the use of this medication, so caution should be exercised when driving or operating machinery. There is a very high possibility of drug interactions, so all medications being taken should be reported to the healthcare provider and managed carefully. Children and elderly patients may respond differently to this medication, so it should be used carefully in these populations. In case of overdose, no specific antidote is available, so the prescribed dosage must be strictly followed, and it should be stored out of reach of children.

Headache, nausea, abdominal pain, rhinitis, sinusitis, upper respiratory tract infection, leukopenia, hypersensitivity, taste disorder, sensory decline, sensory abnormalities, tinnitus, constipation, diarrhea, dyspepsia, bloating, vomiting, abnormal liver function, hyperbilirubinemia, itching, rash, hives, polyuria, erectile dysfunction, menstrual disorders, edema, granulocytopenia, thrombocytopenia, anaphylaxis-like reaction, hyperglycemia, hyperkalemia, hypokalemia, hypomagnesemia, confusion, peripheral neuropathy, dizziness, drowsiness, tremor, heart failure, left ventricular failure, tachycardia, hypertension, hypotension, pulmonary edema, voice disorder, cough, gastrointestinal disorder, liver failure, hepatitis, jaundice, erythematous rash, hyperhidrosis, myalgia, arthralgia, kidney disorder, urinary incontinence, systemic edema, facial swelling, chest pain, fever, pain, fatigue, chills, increased alanine aminotransferase, increased aspartate aminotransferase, increased serum alkaline phosphatase, increased serum lactate dehydrogenase, increased blood urea, increased gamma-glutamyl transferase, increased liver enzymes, abnormal urinalysis, leukocytosis, eosinophilia, anemia, vascular edema, serous disease, angioedema, anaphylaxis, anaphylactic shock, allergic reaction, diplopia, visual impairment, transient hearing loss, permanent hearing loss, ventricular ectopic beats, atrial block, palpitations, increased bowel motility, belching, glossitis, stomatitis, abdominal lumbar pain, pancreatitis, increased serum total protein, increased total bilirubin, increased LAP, decreased appetite, malaise, brown urine, mucous membrane syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Riel syndrome, erythema multiforme, hair loss, photosensitivity reaction, exfoliative dermatitis, leukoclasia vasculitis, acute generalized exanthematous pustulosis, increased BUN, positive urine protein reaction, positive urine glucose reaction, decreased libido, drowsiness, shoulder stiffness, insomnia, chest pain, increased serum triglycerides, flushing, increased serum uric acid, increased serum potassium, serous disease, angioedema, anaphylactic reaction, hypertriglyceridemia, tremor, blurred vision, congestive heart failure, dyspnea, significant hepatic toxicity, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, increased serum creatine phosphokinase

This medication should be stored in a tightly closed container to protect it from air or moisture, and it is important to maintain a storage temperature between 1 and 30 degrees Celsius. Storing it in this manner will help to preserve the effectiveness of the medication and ensure its safe use.

Appearance

A hard capsule with a blue upper part and a pink lower part filled with white or grayish round pellets.

Package unit

30 capsules/bottle, 100 capsules/bottle