Dilatrend SR 16 mg (Carvedilol)

Adult dose

This drug should be taken orally with food. Do not increase the dose or discontinue treatment without your doctor's instructions. This is an extended-release formulation; do not break, crush, or chew it. Swallow the tablet whole. For reference, the daily doses of this extended-release formulation equivalent to those of conventional carvedilol are as follows: Daily dose of conventional formulation Daily dose of extended-release formulation Twice daily, 3.125mg per dose Once daily, 8mg per dose Twice daily, 6.25mg per dose Once daily, 16mg per dose Twice daily, 12.5mg per dose Once daily, 32mg per dose Twice daily, 25mg per dose Once daily, 64mg per dose Twice daily, 50mg per dose Once daily, 128mg per dose 1. Essential hypertension 1) Adults: Administer 16mg once daily for 2 days, then increase to 32mg once daily. Usually, administer 32mg once daily for 2 weeks; if the effect is insufficient, the dose may be increased to 64mg once daily. The maximum daily dose of this drug is 64mg. 2) Elderly patients: A dose of 16mg once daily may provide adequate therapeutic effect. If the effect is insufficient after 2 weeks of treatment, the dose may be increased. Administer cautiously while monitoring the patient's condition. 2. Chronic stable angina 1) Administer 32mg of carvedilol once daily for the first 2 days, then 64mg once daily. 2) Usually, administer 64mg once daily for 2 weeks. If an increase is needed (excluding elderly patients), administer 128mg once daily. 3. Congestive heart failure 1) For initial treatment, administer 8mg of carvedilol once daily for 2 weeks. If the patient tolerates this treatment well, increase to 16mg once daily for 2 weeks, then increase to 32mg once daily for 2 weeks, and then increase to 64mg once daily. 2) After taking each dose for at least 2 weeks, increase the dose gradually to the maximum dose tolerated by the patient. 3) The effective minimum dose of this drug is 16mg once daily. The maximum dose is 64mg once daily for patients weighing 85kg or less and 128mg once daily for patients weighing 85kg or more. 4. Heart rate control in patients with atrial fibrillation Administer 8mg of this drug once daily. If the effect is insufficient after 2 weeks, administer 16mg once daily. If the effect is insufficient after a further 2 weeks, administer 32mg once daily.

This medication affects the heart and blood pressure, thus should not be used in patients with certain heart conditions. For example, it should not be administered to patients with severe cardiac shock or severe cardiac conduction disorders, patients with pulmonary heart disease, or patients with severely compromised cardiac function. Additionally, this medication may exacerbate symptoms in patients with respiratory diseases such as asthma or chronic obstructive pulmonary disease, and should therefore be avoided. It is also safer not to use this medication in patients with metabolic abnormalities due to diabetes, patients with severe liver dysfunction, or in women who are pregnant or breastfeeding. Patients with peripheral circulatory disorders or allergic rhinitis should also exercise caution. Careful administration is required in certain patients such as those with diabetes, the elderly, or patients with impaired kidney function. In particular, patients with very low blood pressure or unstable cardiac function require strict observation by a physician during administration. Also, patients who have had allergic reactions to beta-blockers or have specific allergy histories should exercise caution. During administration, symptoms such as dizziness, headache, and fatigue may occur, and sometimes the heart rate may slow down or symptoms of heart failure may worsen. Side effects like liver function abnormalities, decreased blood pressure, shortness of breath, and skin rashes may also occur, requiring immediate consultation with a healthcare professional if unusual symptoms arise. Regular monitoring of cardiac function, blood pressure, and electrocardiogram is required during long-term administration, and the medication should not be suddenly discontinued but gradually reduced under medical guidance. Particularly in patients with angina, stopping the medication suddenly may lead to exacerbation of symptoms, so caution is necessary. This medication may interact with other drugs, so it is essential to inform healthcare professionals of any currently taken medications, especially blood pressure medications, antidiabetic drugs, antidepressants, and calcium channel blockers. Pregnant or breastfeeding women should not take this medication, and it is recommended that it is not used in children and adolescents as its safety and efficacy have not been established. In elderly patients, drug concentrations may increase due to decreased liver function, thus starting at a lower dosage and carefully monitoring the condition is necessary. In cases of overdose, blood pressure may drop rapidly and heart rate may slow, necessitating immediate notification to healthcare professionals for appropriate treatment. This medication should be stored out of reach of children, and it is safer not to transfer it to another container.

dizziness, headache, fatigue, weakness, hallucination, confusion, depression, sleep disorders, nightmares, psychosis, severe bradycardia, shock, complete heart block, heart failure, cardiac arrest, hypotension, loss of consciousness, limb coldness, edema, deterioration of kidney function, renal failure, increased airway resistance, nausea, diarrhea, abdominal pain, vomiting, constipation, urticaria, itching, lichenoid reactions, allergic rash, thrombocytopenia, leukopenia, hypoglycemia, concealed hyperthyroidism, bradycardia, hypotension, shortness of breath, hypertension in angina, liver dysfunction, jaundice, limb pain, decreased tear production, sensory disturbances, visual disturbances, eye irritation, dry mouth, urinary disorders, sexual dysfunction, allergic reactions, facial paralysis, uterine fibroids, subarachnoid hemorrhage, rib fractures, leg fractures, increased triglycerides, elevated blood glucose, dyspepsia, memory impairment, dizziness, peripheral neuropathy, respiratory distress, nosebleed, cough, productive cough, nasopharyngitis, tinea corporis, soft tissue inflammation, chronic tonsillitis, diverticulitis, nail fungus, sepsis, upper respiratory tract infection, abdominal discomfort, epigastric pain, palpitations, chest discomfort, chest pain, conjunctival congestion, ligament sprain, joint swelling, pruritus, facial flushing, chest discomfort, leg edema, chest pain, back pain, ankle swelling, fever, pain, limb edema, migraine, syncope, blood pressure decrease, increased serum uric acid, increased N-terminal brain natriuretic peptide prohormone, nausea, cardiac flutter, heart failure

This medication should be stored at room temperature between 1°C to 30°C in a sealed container to prevent air from entering. This will maintain the efficacy of the medication and prevent deterioration.

Appearance

Yellow oval sustained-release tablet

Package unit

30 tablets/bottle, 100 tablets/bottle