Dilatrend SR Tablets 8 mg (Carvedilol)

Adult dose

This drug should be taken orally with food. Do not increase the dose or discontinue treatment without your doctor's instructions. This is an extended-release formulation; do not break, crush, or chew it. Swallow the tablet whole. For reference, the daily doses of this extended-release formulation equivalent to those of conventional carvedilol are as follows: Daily dose of conventional formulation / Daily dose of extended-release formulation Twice daily, 3.125mg per dose / Once daily, 8mg per dose Twice daily, 6.25mg per dose / Once daily, 16mg per dose Twice daily, 12.5mg per dose / Once daily, 32mg per dose Twice daily, 25mg per dose / Once daily, 64mg per dose Twice daily, 50mg per dose / Once daily, 128mg per dose 1. Essential hypertension 1) Adults: Administer 16mg once daily for 2 days, then increase to 32mg once daily. Usually, administer 32mg once daily for 2 weeks; if the effect is insufficient, the dose may be increased to 64mg once daily. The maximum daily dose of this drug is 64mg. 2) Elderly patients: A dose of 16mg once daily may provide adequate therapeutic effect. If the effect is insufficient after 2 weeks of treatment, the dose may be increased. Administer cautiously while monitoring the patient's condition. 2. Chronic stable angina 1) Administer 32mg of carvedilol once daily for the first 2 days, then 64mg once daily. 2) Usually, administer 64mg once daily for 2 weeks. If an increase is needed (excluding elderly patients), administer 128mg once daily. 3. Congestive heart failure 1) For initial treatment, administer 8mg of carvedilol once daily for 2 weeks. If the patient tolerates this treatment well, increase to 16mg once daily for 2 weeks, then increase to 32mg once daily for 2 weeks, and then increase to 64mg once daily. 2) After taking each dose for at least 2 weeks, increase the dose gradually to the maximum dose tolerated by the patient. 3) The effective minimum dose of this drug is 16mg once daily. The maximum dose is 64mg once daily for patients weighing 85kg or less and 128mg once daily for patients weighing 85kg or more. 4. Heart rate control in patients with atrial fibrillation Administer 8mg of this drug once daily. If the effect is insufficient after 2 weeks, administer 16mg once daily. If the effect is insufficient after a further 2 weeks, administer 32mg once daily.

This medication should not be used in certain patients. For example, individuals allergic to this medication or its components, patients in cardiogenic shock, those with severe heart conduction abnormalities, patients with cor pulmonale, those with metabolic disorders related to diabetes, individuals with very weak heart function, asthma or chronic obstructive pulmonary disease patients, those with secondary hypertension, patients with very low blood pressure, individuals with severely impaired liver function, and pregnant or breastfeeding women fall into this category. Moreover, diabetic patients, those with a history of severe allergies, individuals with hypotension, those with poor kidney function, the elderly, and hyperthyroid patients should exercise additional caution when using this medication. The medication can affect the central nervous system, causing dizziness, headaches, fatigue, etc., and may produce cardiovascular side effects such as decreased heart rate, lower blood pressure, and worsening of heart failure. Various side effects such as decreased kidney function, respiratory problems, gastrointestinal disturbances, skin rashes, blood abnormalities, and endocrine changes have been reported and require attention. Long-term use necessitates regular monitoring of cardiac function, blood pressure, pulse, etc., as abrupt discontinuation may pose risks of worsening angina or myocardial infarction; thus, it should be tapered gradually as directed by a physician. This medication can interact with several drugs, so when taking it with other antihypertensives, diabetes medications, antidepressants, sedatives, anesthetics, etc., consultation with a physician or pharmacist is advised. During pregnancy or breastfeeding, the risk of side effects occurring in the fetus or newborn may exist, so use should be avoided, and it is not recommended for children or adolescents under 18 years as safety and efficacy have not been confirmed. Elderly patients may retain the drug longer in their system due to decreased liver function; therefore, treatment should start at lower doses and be closely monitored. In cases of overdose, severe blood pressure drops, decreased heart rate, respiratory distress, etc., may occur, necessitating immediate contact with medical institutions for appropriate treatment. Lastly, this medication should be stored out of reach of children and not transferred to other containers for safety.

Dizziness, headache, fatigue, weakness, hallucinations, confusion, depression, sleep disorders, nightmares, psychosis, severe bradycardia, shock, complete atrioventricular block, heart failure, cardiac arrest, significant drop in blood pressure, loss of consciousness, decrease in pulse rate, cold extremities, edema, worsening heart failure, deterioration of kidney function, nephropathy, increased resistance in the respiratory tract, nausea, diarrhea, abdominal pain, vomiting, constipation, urticaria, itching, lichenoid reactions, allergic rash, changes in serum aminotransferases, thrombocytopenia, leukopenia, latent diabetes onset, hypoglycemia, masking of hyperthyroidism, hyperglycemia, weight gain, increased blood cholesterol, bradycardia, hypotension, shortness of breath, hypertension in angina, liver dysfunction, jaundice, limb pain, reduced tear production, sensory disturbance, visual impairment, eye irritation, dry mouth, urination disorders, urinary incontinence, sexual dysfunction, allergic reactions, facial paralysis, uterine fibroids, subarachnoid hemorrhage, rib fractures, leg fractures, peripheral neuropathy, dyspnea, epistaxis, cough, wet cough, nasopharyngitis, body tinea, soft tissue infection, chronic tonsillitis, diverticulitis, nail fungal infection, sepsis, upper respiratory tract infection, abdominal discomfort, upper abdominal pain, palpitations, chest discomfort, chest pain, conjunctival congestion, ligament sprain, joint swelling, pruritus, facial flushing, blood pressure fluctuations, inadequate blood pressure control, chest discomfort, leg edema, chest pain, back pain, ankle swelling, fever, pain, limb edema, migraine, syncope, nausea

This medication should be stored at room temperature between 1°C and 30°C, and it is important to keep it in a sealed container to prevent air from entering. Storing it this way helps maintain the efficacy of the medication and prevents degradation.

Appearance

Pink oblong sustained-release tablet

Package unit

30 tablets/bottle, 100 tablets/bottle