Rexiv Tablet 200 Milligrams (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted for each patient, and it may be taken with or without food. Osteoarthritis (degenerative arthritis): Take celecoxib 200 mg once daily, or 100 mg twice daily in divided doses. Rheumatoid arthritis: Take celecoxib 100 mg or 200 mg twice daily. Ankylosing spondylitis (AS): Administer celecoxib 200 mg once daily, or 100 mg twice daily in divided doses. If no effect is observed after 6 weeks, the dose may be increased to 400 mg daily. If no effect is observed after 6 weeks of taking 400 mg daily, consider other treatment options. Acute pain and primary dysmenorrhea: The initial recommended dose is celecoxib 400 mg, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg twice daily. In patients with moderate hepatic impairment (Child-Pugh Class II), reduce the dose to approximately 50 % of the recommended daily dose.

This medication must be consulted with a doctor or pharmacist for those who regularly consume more than three glasses of alcohol daily. This is because frequent alcohol consumption while taking this medicine may lead to serious side effects, such as gastrointestinal bleeding. This medication can impact the cardiovascular system and may increase the risk of serious thrombotic events, such as myocardial infarction or stroke. Therefore, it should be used at the lowest possible dose and for the shortest duration, and even without a history of cardiovascular disease, symptoms need to be closely monitored. There are also risks to the gastrointestinal system, as ulcers, bleeding, or perforations may occur in the stomach or intestines. Especially elderly patients or those with a history of gastrointestinal disease should be more cautious, and if symptoms such as epigastric pain, dyspepsia, black stools, or hematemesis occur, immediate medical attention should be sought. This medication should not be administered to individuals with specific allergies or diseases. For example, those who are allergic to this medicine or its components, have severe liver or kidney disease, active peptic ulcers, heart failure, or are pregnant should not take it. Individuals with impaired liver or kidney function, or a history of asthma, hypertension, or heart failure should use this medication cautiously and require regular health status checks while on it. Various side effects may occur while taking this medication, including dyspepsia, headache, dizziness, skin rash, hypertension, edema, etc. In severe cases, liver dysfunction, cardiovascular problems, and severe skin reactions may occur, so any symptoms must be reported to a healthcare professional immediately. This medication can interact with other drugs, so be sure to inform your healthcare provider of any ongoing medications, particularly those metabolized by the liver, antihypertensives, anticoagulants, and diuretics. Pregnant or breastfeeding women should not take this medication, and women planning to become pregnant should consult a doctor before taking it. Elderly patients may have decreased renal and hepatic function, so careful monitoring is necessary while taking this medication. Finally, regular blood tests and checks of liver and kidney function should be performed while taking this medication, and if abnormal symptoms occur, treatment should be discontinued immediately and a healthcare professional consulted.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tracts, ulcers, bleeding, bronchitis, sinusitis, upper respiratory infections, urinary tract infections, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disorders, duodenal ulcer, esophageal ulcer, bowel perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, bullous dermatitis, peripheral edema, facial edema, influenza-like illness, injury, headache, leg cramps, sensory attenuation, migraine, neuralgia, neuropathy, sensory disturbances, cerebral infarction, aseptic meningitis, ataxia, suicide, loss of smell, ageusia, back pain, allergy exacerbation, allergic reactions, weakness, chest pain, fluid retention, systemic edema, facial swelling, fatigue, lethargy, fever, facial flushing, influenza syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactic-like reactions, angioedema, loss of appetite, increased appetite, depression, neural hypersensitivity, sleepiness, fatal intracranial hemorrhage, hallucinations, exacerbation of epilepsy, upper respiratory infection, pharyngitis, bronchospasm, exacerbated bronchospasm, dyspnea, laryngitis, pneumonia, nosebleed, voice disorders, vesicular dermatitis, dermatitis, nail disorders, photosensitivity reactions, pruritus, erythematous rash, maculopapular rash, skin disorders, dry skin, increased sweating, erythema multiforme, exfoliative dermatitis, mucocutaneous syndrome, toxic epidermal necrolysis, eczema, lipoma, allergic dermatitis, petechial hemorrhage, dandruff, drug rash, arrhythmia, ventricular hypertrophy, angina, unstable angina, coronary dysfunction, heart failure, palpitations, stroke, aortic valve malfunction, hematoma, bradycardia, syncope, ventricular fibrillation, pulmonary embolism, cerebrovascular accidents, peripheral necrosis, thrombophlebitis, vasculitis, deep vein thrombosis, cerebral hemorrhage, solitary lesions, wound infections, gingivitis, herpes simplex, herpes zoster, bacterial infections, fungal infections, soft tissue infections, viral infections, candidiasis, genital candidiasis, otitis media, mastalgia, menopausal symptoms, fibrocystic breast disease, thoracic neoplasm, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, deafness, liver function abnormalities, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urinary urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, hepatic necrosis, increased serum sodium, increased serum potassium, elevated BUN, increased CPK, diabetes, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, elevated alkaline phosphatase, weight gain, loss of appetite, increased LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, arthrosis, skeletal deformities, myalgia, cervical dystonia, synovitis, tendinitis, myositis, fractures, tendon rupture, pain in the back, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, nosebleed, thrombocytopenic purpura, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, pericarditis, contact dermatitis, injection site reactions, dermal nodules, dysgeusia, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, urinary incontinence, urinary tract infection, blurred vision, cataracts, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, elevated β2-microglobulin, increased NAG, positive urinary hematuria, positive urinary proteinuria, renal dysfunction, acute renal failure, interstitial nephritis, anaphylactic reactions, hallucinations, cerebral hemorrhage, aseptic meningitis, loss of taste, loss of smell, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, liver failure, fulminant hepatitis, hepatic necrosis, bile duct obstruction, bile duct obstruction hepatitis, jaundice, photosensitivity reactions, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug eruptions accompanied by eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, exfoliative dermatitis, acute renal failure, hyponatremia, tubular interstitial nephritis, nephrotic syndrome, minimal change disease glomerulonephritis, menstrual disorders, female infertility

This medication should be stored in a tightly closed container to prevent exposure to air and moisture. It is important to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

White oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle