Sevrelx Capsule 100 mg (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted for each patient, and it may be taken with or without food. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take celecoxib 200 mg once daily, or 100 mg twice daily in divided doses. 2. Rheumatoid arthritis: Take celecoxib 100 mg or 200 mg twice daily. 3. Ankylosing spondylitis (AS): Administer celecoxib 200 mg once daily, or 100 mg twice daily in divided doses. If no effect is observed after 6 weeks, the dose may be increased to 400 mg daily. If no effect is observed after 6 weeks of taking 400 mg daily, consider other treatment options. 4. Acute pain and primary dysmenorrhea: The initial recommended dose is celecoxib 400 mg, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg twice daily. ○ Patients with hepatic impairment: In patients with moderate hepatic impairment (Child-Pugh Class II), reduce the dose to approximately 50% of the recommended daily dose.

This drug may increase the risk of gastrointestinal bleeding in individuals who regularly consume alcohol above a certain amount, so it is essential to consult a physician or pharmacist. This drug may increase the risk of thrombosis in the heart or cerebral blood vessels, so those with a history of cardiovascular disease or risk factors should be particularly cautious. During the use of this drug, it should be taken at a minimum effective dose for the shortest duration possible, and both the physician and patient should carefully monitor for the appearance of cardiovascular symptoms. Because there is a risk of ulcers or bleeding in the stomach, if symptoms such as epigastric pain, indigestion, black stools, or vomiting blood occur, immediate medical attention should be sought. This medication should not be administered to patients with specific allergies, severe liver or kidney dysfunction, pregnant or breastfeeding women, or patients with certain heart diseases. Patients with liver or kidney issues or a history of asthma, hypertension, or heart failure should use this drug cautiously and undergo regular examinations as directed by a physician. This drug may cause various side effects, so any unusual symptoms during use should be reported immediately to medical staff, especially if symptoms such as skin rash, itching, or difficulty breathing occur, in which case the drug should be discontinued immediately and treatment sought. This drug may interact with other medications, so if other medications are being taken, it is essential to inform a physician or pharmacist, particularly when used concurrently with antihypertensives, anticoagulants, antidepressants, or antibiotics. Women who are pregnant or planning to become pregnant should not take this drug and should avoid it while breastfeeding. Elderly patients may have an increased risk of side effects due to impaired kidney, liver, or heart function when taking this drug, so dose adjustments and regular monitoring are necessary. This drug requires regular blood tests and liver and kidney function tests during long-term use, and if any abnormal findings are detected, the medication should be discontinued immediately. Overdose may lead to symptoms such as nausea, vomiting, drowsiness, and gastrointestinal bleeding, so such cases require immediate medical treatment. The safety and efficacy of this drug in children and adolescents have not been established, so its use is not recommended. This drug should be kept out of the reach of children, and it is safest not to transfer it to other containers.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcers, bleeding, bronchitis, sinusitis, upper respiratory infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle hypertonicity, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental diseases, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, vesicular dermatitis, peripheral edema, facial edema, influenza-like illness, damage, headache, leg cramps, sensory impairment, migraine, neuralgia, neuropathy, sensory disturbances, cerebral infarction, aseptic meningitis, ataxia, suicide, anosmia, ageusia, back pain, allergy exacerbation, allergic reactions, weakness, chest pain, fluid retention, systemic edema, facial edema, fatigue, lethargy, fever, facial flushing, influenza syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactic-like reaction, vasculitis, thrombotic venous inflammation, deep vein thrombosis, cerebral hemorrhage, shingles, wound infection, gingivitis, herpes simplex, herpes zoster, bacterial infections, fungal infections, soft tissue infections, viral infections, moniliasis, genital moniliasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic breast disease, thoracic neoplasm, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear disorders, ear pain, hearing impairment, liver dysfunction, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, liver necrosis, increased blood sodium, increased blood potassium, elevated BUN, increased CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, elevated NPN, increased creatinine, elevated alkaline phosphatase, weight gain, loss of appetite, elevated LDH, hypoglycemia, hyponatremia, synovial sac, arthralgia, arthritis, skeletal abnormalities, myalgia, cervical tension, synovitis, tendinitis, myositis, fractures, tendon rupture, back pain, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, nosebleeds, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, phlebitis, contact dermatitis, injection site reaction, skin nodules, dysgeusia, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, urinary incontinence, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased blood creatinine, elevated β2-microglobulin, increased NAG, positive urinary hematuria, positive urinary protein, renal dysfunction, acute renal failure, interstitial nephritis, anaphylactic reaction, hallucination, cerebral hemorrhage, aseptic meningitis, ageusia, anosmia, pulmonary embolism, interstitial pneumonia, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, exfoliative dermatitis, acute renal failure, hyponatremia, tubular interstitial nephritis, nephrotic syndrome, microangiopathic glomerulonephritis, female infertility

This medication should be stored in a tightly closed container to prevent air and moisture exposure, ideally at a cool place between 15 and 30 degrees Celsius. This storage will help maintain the medication's effectiveness for a long time.

Appearance

White to light yellow powder filled in white capsules

Package unit

30 capsules/bottle, 100 capsules/bottle