Olmesartan Medoxomil 40mg Tablet

Adult dose

The recommended initial dose is 10mg once daily, regardless of meals. If blood pressure is not adequately controlled at this dose, it can be increased to 20mg once daily. If further blood pressure reduction is needed, it may be increased to a maximum of 40mg once daily. The blood pressure-lowering effect appears within 2 weeks after starting treatment, and the maximal effect is seen in about 8 weeks. If blood pressure is not controlled with this medication alone, thiazide diuretics such as hydrochlorothiazide can be added. To improve adherence, it is recommended to take it at the same time each day (e.g., in the morning). For patients at risk of intravascular volume depletion (e.g., patients on diuretics, especially those with renal impairment), it is advisable to initiate treatment at lower doses while observing their condition closely. <For elderly patients> No dosage adjustment is necessary for patients aged 65 years and older. Overall differences in efficacy and safety between elderly and younger patients have not been observed; however, more sensitive responses may not be excluded in some elderly individuals. <For patients with renal impairment> The maximum recommended dose for patients with mild to moderate renal impairment (creatinine clearance 20-60mL/min) is 20mg once daily. <For patients with liver impairment> Patients with mild liver impairment do not require dosage adjustments. For patients with moderate liver impairment, the recommended starting dose is 10mg daily, and it can be increased to a maximum of 20mg daily. There is no experience with use in patients with severe liver impairment; therefore, its use is not recommended. <For pediatric patients> The safety and efficacy in pediatric patients have not been established.

Child dose

The safety and efficacy in pediatric patients have not been established.

This medication can cause serious harm to the fetus and newborn if taken during the second and third trimesters of pregnancy, so it must be discontinued immediately if pregnancy is confirmed. Patients allergic to this drug or its ingredients, pregnant or breastfeeding women, patients undergoing renal dialysis, patients with severe liver impairment, patients with biliary obstruction, and patients with lactose intolerance should not take this medication. Patients with reduced blood volume or salt may experience hypotension; thus, their condition should be closely monitored before starting treatment, and appropriate measures should be taken if hypotension occurs. Patients with impaired renal function or kidney transplant recipients may experience changes in renal function while taking this medication, so regular blood tests should be done to check kidney status. Patients at risk of hyperkalemia, especially those with heart failure or renal impairment, should have their serum potassium levels tested periodically. Patients with aortic stenosis or mitral valve stenosis, and those with obstructive heart disease should be particularly cautious when taking this medication. Due to its blood pressure-lowering effects, this medication may cause dizziness; thus, it is advisable to avoid hazardous activities such as working at heights or operating machinery. Combining this medication with potassium-sparing diuretics or potassium supplements may dangerously elevate serum potassium levels, so caution is warranted. Taking this medication together with non-steroidal anti-inflammatory drugs may worsen renal function, so adequate hydration should be ensured, and kidney function monitored regularly. Avoid using this medication in conjunction with lithium preparations, as it may lead to elevated lithium levels and toxicity. Taking this medication during pregnancy may result in serious problems for the fetus, such as hypotension, renal functions decline, or impaired skull development, so it should be discontinued immediately upon discovering pregnancy. Breastfeeding women should discontinue breastfeeding or this medication, as it may affect the baby through breast milk. Safety and efficacy in children have not yet been established. Elderly patients may have higher concentrations of this medication in their body compared to younger individuals, so caution is necessary when dosing. In case of overdose, symptoms such as hypotension, palpitations, and bradycardia may occur, requiring appropriate treatment based on symptoms. This medication is known to have a low risk of carcinogenicity or genotoxicity even with long-term use, but any abnormal symptoms that occur during treatment should be reported to a healthcare professional immediately.

Serious side effects

Urticaria, severe swelling (edema), angioedema, anaphylaxis, chest tightness, difficulty breathing, severe rash along with fever, blisters, skin peeling, pain in oral/ocular mucosa, abnormal liver function test results (increased transaminases or total bilirubin), jaundice (yellowing of skin or eyes), autoimmune hepatitis, acute renal failure, elevated serum creatinine, severe edema, increased blood pressure, serious neurological symptoms (headache,

Mild side effects

Dizziness, headache, palpitations, abdominal pain, dyspepsia, gastroenteritis, nausea, back pain, bronchitis, increased creatine kinase, diarrhea, hematuria, hyperglycemia, hypertriglyceridemia, flu-like symptoms, pharyngitis, rhinitis, sinusitis, cough, epistaxis, upper respiratory infection, hair loss, itching, arthralgia, arthritis, myalgia, weakness, vomiting, chronic malabsorption syndrome-like intestinal disease, rhabdomyolysis, hypercholesterolemia, hyperlipidemia

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture. It is recommended to maintain storage temperatures between 1 and 25 degrees Celsius at room temperature. Proper storage will help preserve the medication's efficacy for a long time.

Appearance

White rectangular film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle